• Allergy
    • 1

      Allergic Response

      By Joud Hajjar, MD; Lawrence B Schwartz, MD, PhD
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      Allergic Response

      • JOUD HAJJAR, MDAllergy and Immunology Fellow, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA
      • LAWRENCE B SCHWARTZ, MD, PHDCharles & Evelyn Thomas Professor of Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA

      The term hypersensitivity refers to diseases caused by an immune response, regardless of whether the response is against a pathogen, nonpathogen, or self and regardless of whether the response is directed by antibodies, lymphocytes, or innate pathways. The term anaphylaxis was coined in 1902 by Charles Richet, who received the Nobel Prize in 1913; this systemic allergic response is now known to be an immediate hypersensitivity reaction, initiated by allergen delivered to a host having allergen-specific IgE, thereby causing an IgE-mediated immunologic response and activating mast cells and basophils to secrete bioactive mediators. In 2005, the National Institutes of Health organized a consensus conference to develop a working definition of anaphylaxis, designed to be used by physicians at the bedside, as a serious allergic reaction that is rapid in onset, typically eliciting various combinations of cutaneous, cardiovascular, respiratory, and gastrointestinal manifestations, and may cause death.1,2 This facilitated the early treatment of such patients with epinephrine. Confusion arises over the misapplication of the term allergy or hypersensitivity to describe any untoward reaction to food, medications, or environmental exposures. Furthermore, non–IgE-mediated forms of local and systemic mast cell or basophil activation events can occur, causing signs and symptoms similar to those mediated by IgE. 

      This review contains 3 figures, 9 tables, and 62 references.

      Keywords: allergy, hypersensitivity, anaphylaxis, interleukin, chemokines, immunoglobulin E, mast cell, eosinophil

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    • 2

      Allergic Response

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      Allergic Response

      The term hypersensitivity refers to diseases caused by an immune response, regardless of whether the response is against a pathogen, nonpathogen, or self and regardless of whether the response is directed by antibodies, lymphocytes, or innate pathways. The term anaphylaxis was coined in 1902 by Charles Richet, who received the Nobel Prize in 1913; this systemic allergic response is now known to be an immediate hypersensitivity reaction, initiated by allergen delivered to a host having allergen-specific IgE, thereby causing an IgE-mediated immunologic response and activating mast cells and basophils to secrete bioactive mediators. In 2005, the National Institutes of Health organized a consensus conference to develop a working definition of anaphylaxis, designed to be used by physicians at the bedside, as a serious allergic reaction that is rapid in onset, typically eliciting various combinations of cutaneous, cardiovascular, respiratory, and gastrointestinal manifestations, and may cause death.1,2 This facilitated the early treatment of such patients with epinephrine. Confusion arises over the misapplication of the term allergy or hypersensitivity to describe any untoward reaction to food, medications, or environmental exposures. Furthermore, non–IgE-mediated forms of local and systemic mast cell or basophil activation events can occur, causing signs and symptoms similar to those mediated by IgE. 

      This review contains 3 figures, 9 tables, and 62 references.

      Keywords: allergy, hypersensitivity, anaphylaxis, interleukin, chemokines, immunoglobulin E, mast cell, eosinophil

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    • 3

      Allergic Rhinitis, Conjunctivitis, Sinusitis

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      Allergic Rhinitis, Conjunctivitis, Sinusitis

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    • 4

      Urticaria and Angioedema

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      Urticaria and Angioedema

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    • 5

      Anaphylaxis

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      Anaphylaxis

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    • 6

      Allergic Reaction to Drugs, Food, and Environment

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      Allergic Reaction to Drugs, Food, and Environment

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    • 7

      Drug Allergies

      By Aimee L. Speck, MD; James L Baldwin, MD
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      Drug Allergies

      • AIMEE L. SPECK, MDFellow, Division of Allergy and Clinical Immunology, University of Michigan School of Medicine, Ann Arbor, MI
      • JAMES L BALDWIN, MDDivision Chief, Division of Allergy and Clinical Immunology, Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI

      Adverse drug reactions (ADRs) are an important public health problem. An ADR is defined by the World Health Organization as an unintended, noxious response to a drug that occurs at a dose usually tolerated by normal subjects. The classification of ADRs by Rawlins and Thompson divides ADRs into two major subtypes: (1) type A reactions, which are dose dependent and predictable, and (2) type B reactions, which are uncommon and unpredictable. The majority of ADRs are type A reactions, which include four subtypes: overdosage or toxicity, side effects, secondary effects, and interactions. Type B reactions constitute approximately 10 to 15% of all ADRs and include four subtypes: drug intolerance, idiosyncratic reactions, pseudoallergic reactions, and drug hypersensitivity reactions. This chapter reviews the epidemiology of ADRs, risk factors for drug hypersensitivity reactions, the classification of drug reactions, diagnostic tests, reactions to specific drugs, and management of the patient with drug allergy. Figures illustrate drugs as haptens and prohaptens, the Gell and Coombs system, the four basic immunologic mechanisms for drug reactions, the chemical structure of different β-lactam antibiotics, penicillin skin testing, sulfonamide metabolism and haptenation, nonsteroidal antiinflammatory drug effects, and patient management. Tables outline the classification of ADRs, drugs frequently implicated in allergic drug reactions, and reagents and concentrations recommended for prick and intradermal skin testing.

      This review contains 8 figures, 7 tables, and 60 references.

      Key Words: Adverse drug reactions, drug hypersensitivity reactions, overdosage, toxicity, Type A reactions, Type B reactions, human leukocyte antigen, pruritus, angioedema, urticarial, bronchospasm, laryngeal edema, rhinoconjunctivitis


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    • 8

      Food Allergies

      By Matthew Greenhawt, MD, MBA, MSc
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      Food Allergies

      • MATTHEW GREENHAWT, MD, MBA, MSCAssistant Professor, Division of Allergy and Clinical Immunology, University of Michigan Medical School, University of Michigan Health System, Ann Arbor, MI

      Food allergy represents a rapidly growing public health problem in the United States and other westernized nations. Adverse reactions to foods are categorized as either immunologic or nonimmunologic reactions. This distinction is highly important but often confusing to patients and physicians unfamiliar with allergy, who may simply describe any adverse reaction to a food as an “allergy.” A food allergy is an immune-mediated, adverse reaction to one or more protein allergens in a particular food item involving recognition of that protein by specifically targeted IgE or allergen-specific T cells. This chapter discusses the definition, pathophysiology, epidemiology, testing, management, prognosis, and natural history of food allergy. Clinical manifestations are systematically covered, including cutaneous, respiratory, cardiovascular, and gastrointestinal reactions, as well as eosinophilic esophagitis, food protein–induced enterocolitis syndrome, and oral allergy syndrome. Emerging treatments such as food oral immunotherapy are also reviewed. Tables outline signs and symptoms of immediate hypersensitivity reactions to food, the prevalence of major food allergens in the United States, common patterns of cross-reactivity among foods, clinical criteria for the diagnosis of anaphylaxis, and clinical studies involving treatment for food allergies. Figures illustrate the classification of adverse reactions to food, esophageal histology, visual and radiographic features of eosinophilic esophagitis, and a food allergy action plan.

      This review contains 4 figures, 8 tables, and 64 references.

      KeyWords: Food allergy, Hypersensitivity, IgE-mediated allergy, Eosinophilic esophagitis, Anaphylaxis



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    • 9

      Allergic Rhinitis, Conjunctivitis, and Sinusitis

      By Robert Naclerio, MD
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      Allergic Rhinitis, Conjunctivitis, and Sinusitis

      • ROBERT NACLERIO, MDProfessor and Chief, Department of Surgery, Section of Otolaryngology, Head and Neck Surgery, University of Chicago, Chicago, IL

      Allergic rhinitis is an IgE-mediated inflammatory response in the nose to foreign substances known as allergens. It can be classified as seasonal or perennial, depending on the allergens triggering the reaction. This characterization is good for identifying allergen triggers but is limited because it is based on the duration of outdoor exposure (e.g., grass pollinates for 2 months in Chicago and nearly 11 months in Texas). Also, some perennial allergens, such as dust mites, have seasons. The Allergic Rhinitis in Asthma (ARIA) classification was developed to focus on therapy. It assumes that exposure to perennial and to seasonal allergen leads to the same immunologic response. ARIA places patients into the categories of mild intermittent, mild persistent, moderate/severe intermittent, and moderate/severe persistent to recommend treatment and emphasizes the link between allergic rhinitis and asthma.1

      This review contains 5 figures, 9 tables, and 56 references.

      Key Words: Sinusitis, infection, allergy, antibiotic, decongestant, antihistamine


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  • Cardiovascular
    • 1

      Unstable Angina and Acute Coronary Syndrome

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      Unstable Angina and Acute Coronary Syndrome

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    • 2

      Other Cardiac Arrhythmias

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      Other Cardiac Arrhythmias

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    • 3

      Structural Heart Abnormalities

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      Structural Heart Abnormalities

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    • 4

      Diseases of the Aorta

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      Diseases of the Aorta

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    • 5

      Peripheral Artery and Vascular Disease

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      Peripheral Artery and Vascular Disease

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    • 6

      Hyperlipidemia

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      Hyperlipidemia

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    • 7

      Hypertension

      By Marc P Bonaca, MD, MPH
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      Hypertension

      • MARC P BONACA, MD, MPHVascular Section, Cardiovascular Division, Brigham and Women’s Hospital, Assistant Professor, Harvard Medical School, Boston, MA

      Hypertension is a common chronic disorder with an increasing prevalence in the context of an aging population. Patients with hypertension are at risk for adverse cardiovascular, renal, and neurologic outcomes. Treatment of hypertension reduces this associated risk; therefore, early diagnosis and systematic management are critical in reducing morbidity and mortality. Although hypertension is multifactorial, a large component is related to lifestyle, including excess sodium intake, lack of physical activity, and obesity. Lifestyle intervention and education, therefore, are critical to both prevention and treatment of hypertension. Patients diagnosed with hypertension should be evaluated for their overall risk, with specific therapies and treatment targets guided by their characteristics and comorbidities. Several professional and guideline societies have published recommendations with regard to the diagnosis and treatment of hypertension, which have many similarities but also several areas of discussion and ongoing debate. Recent evolutions in the field include the expanded indications for home-based and ambulatory blood pressure monitoring and outcomes trials, which add important data regarding optimal treatment targets. These evolutions are likely to be addressed in ongoing guideline updates.

      Key words: ambulatory blood pressure monitoring, antihypertensive therapy, blood pressure, blood pressure targets, cardiovascular risk, high blood pressure, home blood pressure monitoring, hypertension, screening, secondary hypertension

      This review contains 9 figures, 13 tables, and 59 references.

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    • 8

      Atrial Fibrillation

      By Gregory F. Michaud, MD; Roy M. John, MD, PhD
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      Atrial Fibrillation

      • GREGORY F. MICHAUD, MDDirector, Center for the Advanced Management of Atrial Fibrillation, Brigham and Women’s, Hospital, Assistant Professor of Medicine, Harvard Medical School, Boston, MD
      • ROY M. JOHN, MD, PHDAssociate Director EP Laboratory, Director, Experimental Research, Cardiac Arrhythmia Service, Brigham and Women’s Hospital, Assistant Professor of Medicine, Harvard Medical School, Boston, MA

      Atrial fibrillation (AF) is an abnormal rhythm characterized by chaotic atrial electrical activity resulting in loss of atrial contraction, an irregular and unpredictable heart rate, and a tendency for thrombus formation. The prevalence of AF is estimated at 1 to 2%, but it’s likely higher than that because one-third of patients may have no symptoms and might never seek medical attention. Data suggest that 1 in 4 people over the age of 40 will develop AF in their lifetime. About 10% of patients over age 80 have experienced the arrhythmia, and some estimates predict the prevalence will double in the next 50 years. This chapter discusses the pathophysiology, genetics, diagnosis, classification, and treatment of AF. Figures show atrial fibrillation and coarse atrial fibrillation plus common right atrial flutter. One algorithm is for oral anticoagulation therapy, and a second shows a recommended hierarchical choice of antiarrhythmic therapies versus catheter ablation for recurrent symptomatic atrial fibrillation. Tables list classification, diagnostic evaluation of, clinical consequences of, and conditions often associated with atrial fibrillation. Three scoring systems are included: 1) for congestive heart failure, hypertension, diabetes, stroke, and transient ischemic attack; 2) to assess the risk of bleeding with oral anticoagulation, and 3) data and proportion of patients from the Euro Heart Survey. Other tables include long-term anticoagulation guidelines for atrial fibrillation, intravenous drugs used for acute rate control, oral drugs used for chronic rate control, and antiarrhythmic drugs for conversion of atrial fibrillation and/or maintenance of sinus rhythm. In addition, there’s a summary of randomized trials weighing rate control and rhythm control strategies, plus schemes for categorizing thromboembolism risk.

      This review contains 4 highly rendered figures, 14 tables, and 129 references.

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    • 9

      Chronic Stable Angina

      By J. Antonio T. Gutierrez, MD; Benjamin J Scirica, MD, MPH
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      Chronic Stable Angina

      • J. ANTONIO T. GUTIERREZ, MDCardiovascular Medicine Fellow, Brigham and Women's Hospital, Boston, MA
      • BENJAMIN J SCIRICA, MD, MPHSenior Investigator, TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Associate Professor of Medicine, Harvard Medical School, Boston, MA

      By definition, chronic stable angina is angina that has been stable with regard to frequency and severity for at least 2 months. Chronic stable angina is the initial manifestation of coronary heart disease in approximately 50% of patients. Typically, this type of angina occurs in the setting of atherosclerotic coronary arterial narrowing, although other causes are possible. This review covers the epidemiology, pathophysiology, initial evaluation, differential diagnosis, management, and treatment of patients with chronic stable angina. Figures show noninvasive testing and the probability of coronary artery disease; diagnosis of patients with suspected ischemic heart disease; probability of severe coronary artery disease; coronary outcomes for high- versus low-intensity statin therapy; optimal medical therapy (OMT) versus OMT and percutaneous coronary intervention for chronic angina; OMT versus percutaneous coronary intervention for stable coronary heart disease; and coronary artery bypass grafting versus percutaneous coronary intervention for diabetes and coronary artery disease. Tables list the grading of angina pectoris by the Canadian Cardiovascular Society classification system, the differential diagnosis of chest pain, conditions promoting myocardial oxygen supply and demand mismatch, the features of typical angina, the classification of chest pain, a comparison of the pretest likelihood of coronary heart disease (CHD) in low-risk and high-risk symptomatic patients, the posttest probability of significant CHD based on pretest probabilities of CHD and normal or abnormal results of noninvasive studies, survival according to risk groups based on Duke treadmill scores, high- and moderate-intensity statin therapy, revascularization to improve survival compared with medical therapy, revascularization to improve symptoms with significant anatomic (≥ 50% left main or ≥ 70% nonleft main coronary artery disease) or physiologic (fractional flow reserve ≤ 0.80) coronary artery stenoses, and questions recommended by an expert panel for patients with chronic stable angina at follow-up visits.

      This review contains 7 highly rendered figures, 13 tables, and 109 references.

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    • 10

      Heart Failure

      By Sachin P Shah, MD; Mandeep R. Mehra, MD
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      Heart Failure

      • SACHIN P SHAH, MDCenter for Advanced Heart Disease, Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, Director, Cardiovascular Intensive Care Unit, Lahey Hospital and Medical Center, Burlington, MA
      • MANDEEP R. MEHRA, MDMedical Director, Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA

      Heart failure is a syndrome related to abnormal cardiac performance with a consequence of impaired cardiac output at rest or with exertion and/or congestion, which usually leads to symptoms of fatigue, dyspnea, and edema. The syndrome is characterized by various phenotypes related to a vast array of etiologies with diverse management targets. The current broad categorization of heart failure separates patients based on ejection fraction. Further description of the phenotype beyond ejection fraction is imperative to correctly identify the etiology of heart failure and, ultimately, to choose medical, device, and surgical therapies appropriately. This review covers the epidemiology of heart failure, defining the phenotype and etiology of heart failure, recognition and management of acute decompensated heart failure, management of chronic heart failure with a reduced ejection fraction, implantable cardioverter-defibrillators in heart failure with a reduced ejection fraction, management of heart failure with a preserved ejection fraction, and advanced heart failure. Figures show the evolution of therapy in chronic heart failure from the symptom-directed model, the complex pathophysiology and principal aberrations underlying heart failure with preserved ejection fraction, and concepts underlying surgical therapy in advanced heart failure using Laplace’s law. Tables list various etiologies of heart failure; sensitivity and specificity of clinical, biomarker, and radiographic data in the diagnosis of acute decompensated heart failure; drugs and devices with a demonstrated survival benefit in heart failure with a reduced ejection fraction; neurohormonal antagonist dosing in heart failure with a reduced ejection fraction; randomized, placebo-controlled trials in heart failure with a preserved ejection fraction; categorization of heart failure according to American Heart Association/American College of Cardiology heart failure stage, New York Heart Association functional class, and Interagency Registry for Mechanically Assisted Circulatory Support level; and poor prognostic indicators in heart failure.

      This review contains 3 highly rendered figures, 9 tables, and 58 references.

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    • 11

      Venous Thromboembolism

      By Daniel J. Corrigan, MD; Christopher Kabrhel, MD, MPH
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      Venous Thromboembolism

      • DANIEL J. CORRIGAN, MDResident, Harvard Affiliated Emergency Medicine Residency Program, Brigham and Women’s Hospital and Massachusetts General Hospital, Resident, Department of Emergency Medicine, Harvard Medical School, Boston, MA
      • CHRISTOPHER KABRHEL, MD, MPHDirector, Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Associate Professor of Emergency Medicine, Department of Emergency Medicine, Harvard Medical School, Boston, MA

      Venous thromboembolism (VTE) encompasses both deep vein thrombosis (the development of clots in the large veins of the extremities, with the deposition of clotting factors, platelets, and red blood cells) and pulmonary embolism (which occurs when a portion of a clot dislodges, travels through the right heart, and embeds in the pulmonary vasculature). Risk factors for VTE include recent surgery, extremity trauma, age, obesity, smoking, cancer, antiphospholipid antibody syndrome, and inherited risk factors, such as factor V Leiden. This review details the epidemiology and risk factors, pathophysiology, stabilization and assessment, supportive care and empirical therapy, diagnosis, treatment, and outcomes of patients with venous thromboembolism. Figures show the pathophysiology of right heart failure in acute pulmonary embolism; a venous sonogram showing a large acute deep vein thrombosis in a dilated, noncompressible right common femoral vein in cross section; and a computed tomographic pulmonary angiography demonstrating intraluminal filling defects caused by pulmonary embolism in the lobar artery of the left lower lobe and the main artery of the right lung in a patient with chest deformity. Tables list risk factors for VTE, the Wells score, the revised Geneva score for PE, and pulmonary embolism rule-out criteria.

      This review contains 3 highly rendered figures, 11 tables, and 49 references.

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    • 12

      Risk Factors and Epidemiology of Pulmonary Embolism

      By Aaron W Aday, MD; Aaron B Waxman, MD, PhD
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      Risk Factors and Epidemiology of Pulmonary Embolism

      • AARON W ADAY, MDDivision of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
      • AARON B WAXMAN, MD, PHDPulmonary and Critical Care Medicine, Director, Pulmonary Vascular Disease Program, Executive Director, Center for Pulmonary-Heart Diseases, Brigham and Women’s Hospital Heart and Vascular Center, Associate Professor of Medicine/Harvard Medical School, Boston, MA

      More than 200,000 individuals are hospitalized with an acute pulmonary embolism in the United States annually. Despite advances in diagnosis and treatment, pulmonary embolism accounts for nearly 1% of all cardiovascular-related deaths each year in the United States alone. Those who survive an acute episode remain at a risk of recurrent events as well as ongoing dyspnea, reduced quality of life, and chronic thromboembolic pulmonary hypertension. Recognized risk factors for pulmonary embolism include advanced age, obesity, smoking, malignancy, immobilization from any cause, pregnancy and the postpartum period, oral contraceptives, and hormone replacement therapy. Numerous heritable and acquired thrombophilias increase the risk of pulmonary embolism. Additionally, inflammation and autoimmune disorders are increasingly recognized as potent risk factors for pulmonary embolism.

      This review contains 3 figures, 5 tables, 54 references.

      Key Words: anticoagulation, deep vein thrombosis, epidemiology, genetics, inflammation, malignancy, pulmonary embolism, thrombosis, venous thromboembolism

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    • 13

      Aortic Valve Stenosis

      By Stephen H Little, MD, FRCPC, FACC, FASE; Jeffrey R Parker, MD
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      Aortic Valve Stenosis

      • STEPHEN H LITTLE, MD, FRCPC, FACC, FASEMedical Director, Valve Clinic, Houston Methodist Hospital, Houston, TX, United States
      • JEFFREY R PARKER, MDHouston Methodist Hospital, Houston, TX, United States

      Valvular heart disease is a common clinical syndrome that physicians face on a routine basis. Aortic stenosis (AS) accounts for a substantial amount of these cases with differing etiologies from rheumatic, congenital bicuspid to calcific AS. Clinical history and physical examination can assist in assessing the presence and severity of AS, but echocardiography has been the gold standard for the diagnosis of AS and to assess severity. Multimodality imaging including cardiac computed tomography, magnetic resonance imaging, and 3D printing have evolved over the years, lending aid in the diagnosis and prognostication of AS. This review provides a succinct overview of the prevalence, pathophysiology, clinical assessment, and diagnosis of AS.

      This review contains 10 figures and 48 references.

      Key Words: aortic stenosis, cardiac computed tomography, cardiac magnetic resonance imaging, 3D printing, low-flow low-gradient aortic stenosis

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  • Competency Based Patient Care
  • Dermatology
    • 1

      Papulosquamous Disorders

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      Papulosquamous Disorders

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    • 2

      Cutaneous Adverse Drug Reactions 

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      Cutaneous Adverse Drug Reactions 

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    • 3

      Psoriasis

      By Mark Lebwohl, MD; Elizabeth A Abel, MD
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      Psoriasis

      • MARK LEBWOHL, MDSol and Clara Kest Professor and Chairman, Department of Dermatology, Mount Sinai School of Medicine, New York City, NY
      • ELIZABETH A ABEL, MDAdjunct Clinical Professor of Dermatology, Stanford University School of Medicine, Stanford, CA, Private Practice, California Skin Institute, Mountain View, CA

      Psoriasis is an immune-mediated inflammatory cutaneous disorder characterized by chronic, scaling, erythematous patches and plaques of skin. It can begin at any age and can vary in severity. Psoriasis can manifest itself in several different forms, including pustular and erythrodermic forms. In addition to involving the skin, psoriasis frequently involves the nails, and some patients may experience inflammation of the joints (psoriatic arthritis). Because of its highly visible nature, psoriasis can compromise both the personal and the working lives of its victims. Breakthroughs in the treatment of psoriasis have led to a better understanding of its pathogenesis.

      This review contains 12 figures, 8 tables, and 79 references.

      Keywords: Psoriases, Pustulosis of Palms and Soles, Pustulosis Palmaris et Plantaris, Palmoplantaris Pustulosis, Pustular Psoriasis of Palms and Soles

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    • 4

      Infestations

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      Infestations

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    • 5

      Malignant Cutaneous Tumors

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      Malignant Cutaneous Tumors

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    • 6

      Benign Cutaneous Tumors

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      Benign Cutaneous Tumors

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    • 7

      Acne Vulgaris and Rosacea

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      Acne Vulgaris and Rosacea

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    • 8

      Disorders of the Hair

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      Disorders of the Hair

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    • 9

      Disorders of the Nail

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      Disorders of the Nail

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    • 10

      Disorder of Pigmentation

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      Disorder of Pigmentation

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    • 11

      Pruritus

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      Pruritus

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    • 12

      Cutaneous Manifestations of Systemic Diseases

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      Cutaneous Manifestations of Systemic Diseases

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    • 13

      Skin Procedures: Biopsy Techniques, Incision/drainage, and Steroid Injections

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      Skin Procedures: Biopsy Techniques, Incision/drainage, and Steroid Injections

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    • 14

      Eczematous Disorders, Atopic Dermatitis, and Ichthyoses

      By Seth R Stevens, MD
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      Eczematous Disorders, Atopic Dermatitis, and Ichthyoses

      • SETH R STEVENS, MDPartner Physician, Southern California Permanente Medical Group, Woodland Hills, CA, and Assistant Clinical Professor, Case Medical School, Cleveland, OH

      This review describes eczematous dermatitis, or eczema, a skin disease that is characterized by erythematous vesicular, weeping, and crusting patches; atopic dermatitis, a common chronic inflammatory dermatosis that generally begins in infancy; and the ichthyoses, a group of diseases of cornification that are characterized by excessive scaling. The purpose of this review is to examine the major variants, epidemiology, etiology, diagnosis, differential diagnosis, and treatment of these dermatologic diseases. Figures depict chronic eczematous dermatitis, allergic contact dermatitis to poison ivy, seborrheic dermatitis, nummular eczema, acute eczematous patches, lichenified patches that appear after chronic rubbing of eczematous patches, erythroderma (total body erythema), and marked scaling (acquired ichthyosis). Tables list the diagnostic criteria for atopic dermatitis and the differential diagnosis of atopic dermatitis.

      This review contains 9 highly rendered figures, 2 tables, and 88 references.

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    • 15

      Skin Infections

      By Jan V. Hirschmann, MD
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      Skin Infections

      • JAN V. HIRSCHMANN, MDProfessor of Medicine, University of Washington School of Medicine, Staff Physician, Puget Sound VA Medical Center, Seattle, WA

      The skin can become infected by viruses, fungi, and bacteria, including some that ordinarily are harmless colonizing organisms. The most common fungal infections are caused by dermatophytes, which can involve the hair, nails, and skin. Potassium hydroxide (KOH) preparations of specimens from affected areas typically demonstrate hyphae, and either topical or systemic antifungal therapy usually cures or controls the process. The most common bacterial pathogens are Staphylococcus aureus and group A streptococci, which, alone or together, can cause a wide variety of disorders, including impetigo, ecthyma, and cellulitis. Topical antibiotics may suffice for impetigo, but ecthyma and cellulitis require systemic treatment. S. aureus, including methicillin-resistant strains, can also cause furuncles, carbuncles, and cutaneous abscesses. For these infections, incision and drainage without antibiotics are usually curative. Warts are the most common cutaneous viral infection, and eradication can be difficult, especially where the skin is thick, such as the palms and soles, or the patient is immunocompromised. Most therapies consist of trying to destroy the viruses by mechanical, chemical, or immune mechanisms. This review covers dermatophyte infections, yeast infections, bacterial infections, and viral infections of the skin. Figures show the classic annular lesion of tinea corporis, a typical kerion presenting as a zoophilic Microsporum canis infection of the scalp (tinea capitis), tinea corporis, tinea barbae, tinea pedis between and under the toes and on the plantar surface, inflammatory tinea pedis, tinea unguium, tinea manuum, angular cheilitis, prominent satellite lesions of discrete vesicles associated with candidiasis, facial candidiasis, Candida paronychia, tinea versicolor, nonbullous impetigo, bullous impetigo, ecthyma, leg cellulitis, erythema and edema on the cheeks, eyelids, and nose, furuncle, carbuncle, nasal folliculitis, pitted keratolysis, trichomycosis axillaris, necrotizing fasciitis, Fournier gangrene, folliculitis, plantar wart, condyloma acuminatum, and benign lesions of bowenoid papulosis. Tables list dermatophyte species, terminology of dermatophyte infections, topical agents for dermatophyte infections, treatment options for impetigo (adult doses), and treatment options for erythrasma.

       

      This review contains 28 highly rendered figures, 5 tables, and 33 references

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  • Endocrine
    • 1

      Diseases of the Adrenal Glands

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      Diseases of the Adrenal Glands

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    • 2

      Cushing Syndrome

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      Cushing Syndrome

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    • 3

      The Pituitary

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      The Pituitary

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    • 4

      Diseases of Calcium Metabolism and the Parathyroid

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      Diseases of Calcium Metabolism and the Parathyroid

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    • 5

      Bone Disease Including Osteoporosis and Osteopenia

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      Bone Disease Including Osteoporosis and Osteopenia

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    • 6

      Testes and Testicular Disorders

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      Testes and Testicular Disorders

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    • 7

      Type I DM

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      Type I DM

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    • 8

      Type II DM (including Complications)

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      Type II DM (including Complications)

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    • 9

      Secondary Forms of DM

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      Secondary Forms of DM

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    • 10

      Hypoglycemia

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      Hypoglycemia

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    • 11

      Obesity

      Obesity and its associated disorders are leading causes of morbidity and premature mortality around the world. Obese persons are also vulnerable to low self-esteem and depression because of the psychological and social stigmata that often accompany being overweight. Despite conventional wisdom that obesity results from deficient self-control, research has provided insight into the physiology behind unwanted weight gain. Obesity is recognized as a chronic condition resulting from an interaction between environmental influences and an individual’s genetic predisposition.

      This review contains 3 figures, 12 tables, and 125 references.

      Keywords: Obesity, Body mass index, Hypertension, impaired glucose tolerance or diabetes, hyperlipidemia, heart disease, pulmonary disease, gastroesophageal reflux, sleep apnea

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    • 12

      Dyslipidemia

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      Dyslipidemia

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    • 13

      Type I Diabetes Mellitus

      By Katharine Garvey, MD, MPH; Joseph I. Wolfsdorf, MB, BCh
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      Type I Diabetes Mellitus

      • KATHARINE GARVEY, MD, MPHInstructor of Pediatrics, Harvard Medical School, Boston, MA
      • JOSEPH I. WOLFSDORF, MB, BCHProfessor of Pediatrics, Harvard Medical School, Boston, MA

      Type 1 diabetes mellitus is characterized by severe insulin deficiency, making patients dependent on exogenous insulin replacement for survival. These patients can experience life-threatening events when their glucose levels are significantly abnormal. Type 1 diabetes accounts for 5 to 10% of all diabetes cases, with type 2 accounting for most of the remainder. This review details the pathophysiology, stabilization and assessment, diagnosis and treatment, disposition and outcomes of patients with Type 1 diabetes mellitus. Figures show the opposing actions of insulin and glucagon on substrate flow and plasma levels; plasma glucose, insulin and C-peptide levels throughout the day; the structure of human proinsulin; current view of the pathogenesis of Type 1 autoimmune diabetes mellitus; pathways that lead from insulin deficiency to the major clinical manifestations of Type 1 diabetes mellitus; relationship between hemoglobin A1c values at the end of a 3-month period and calculated average glucose levels during the 3-month period; different combinations of various insulin preparations used to establish glycemic control; and basal-bolus and insulin pump regimens. Tables list the etiologic classification of Type 1 diabetes mellitus, typical laboratory findings and monitoring in diabetic ketoacidosis, criteria for the diagnosis of Type 1 diabetes, clinical goals of Type 1 diabetes treatment, and insulin preparations.

      This review contains 10 figures, 8 tables, and 40 references.

      Keywords: Type 1 diabetes mellitus, optimal glycemic control, hypoglycemia, hyperglycemia, polyuria, polydipsia, polyphagia, HbA1c, medical nutrition therapy, Diabetic Ketoacidosis

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    • 14

      Type II Diabetes Mellitus

      By Saul Genuth, MD, FACP; Matthew C. Riddle, MD
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      Type II Diabetes Mellitus

      • SAUL GENUTH, MD, FACPProfessor, Division of Clinical and Molecular Endocrinology, Case Western Reserve University School of Medicine, Cleveland, OH
      • MATTHEW C. RIDDLE, MDProfessor, Department of Medicine, and Head, Section of Diabetes, Oregon Health & Sciences University, Portland, OR

      Hyperosmotic hyperglycemic nonketotic (HHNK) state (also known as hyperosmolar hyperglycemic state) is a significant acute complication of type 2 diabetes mellitus, especially for those over 65 years of age. It is characterized by extreme hyperglycemia and hyperosmolarity with little ketosis. The main clinical effect of extreme hyperosmolarity is somnolence or confusion. The absence of severe ketonemia is attributed to residual insulin secretion that is sufficient to restrain lipolysis. HHNK state is marked by extreme dehydration, with both a marked deficit of free water and serious compromise of intravascular volume and tissue perfusion. Most patients with HHNK state have hypotension, extremely dry mucous membranes, and gross elevation of urea nitrogen and creatinine. Urinary tract infection, pneumonia, stroke, myocardial infarction, and sepsis may precipitate HHNK state. Elderly patients are particularly vulnerable because their thirst mechanisms are less sensitive to a rising serum osmolality. Fluid replacement is the most important component of therapy for HHNK state. Restoration of circulating volume is an urgent first priority and is accomplished by relatively rapid intravenous infusion of 2 L of 0.9% normal saline followed by 0.45% normal saline. Later, when plasma glucose levels have declined to 250 to 300 mg/dL, 5% dextrose in water is given. Insulin treatment is started soon after administration of isotonic saline. Potassium must be added to intravenous fluids to prevent hypokalemia caused by insulin action but should not be started until hypokalemia is proven, because potassium levels can be high initially. The mortality from the HHNK state is high, ranging from 10 to 20%, and is most often from the precipitating illness.

      This review contains 6 figures, 6 tables, and 74 references.

      Key words: dehydration, fluid deficit, hyperglycemia, hyperglycemic nonketotic state, hyperosmolar, hyperosmotic insulin, potassium, type 2 diabetes mellitus

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    • 15

      Hypothyroidism and Thyrotoxicosis

      By Paul W. Ladenson, MD
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      Hypothyroidism and Thyrotoxicosis

      • PAUL W. LADENSON, MDJohn Eager Howard Professor of Endocrinology & Metabolism, Professor of Medicine, Pathology, Oncology, Radiology & Radiological Sciences, and International Health, University Distinguished Service Professor, Director, Division of Endocrinology & Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland

      Thyroid disorders are the most common endocrine conditions encountered in clinical practice and can range from clinically obvious to clinically silent. This review provides the definition and epidemiology of the conditions of hypothyroidism and hyperthyroidism. Hypothyroidism can be congenital or acquired, and its pathogenesis, diagnosis, and management are presented. The three most common disorders of thyrotoxicosis (diffuse toxic goiter [Graves disease], toxic nodular goiter, and iatrogenic thyrotoxicosis in thyroid hormone–treated patients are addressed, as well as the many diseases in each of these categories. This review also discusses thyroiditis, goiter, thyroid nodules, and thyroid cancer. Tables list the causes of elevated serum thyroid-stimulating hormone (TSH) levels, the etiologic classification of thyrotoxicosis, characteristic features of thyroiditis, and causes of elevated serum total thyroxine levels. Figures show the prevalence of abnormalities in thyroid function tests in different populations, certain forms of hyperthyroidism that result from pathophysiologic activation of the TSH receptor, and inflammation of thyroid tissue in acute thyroiditis.

      This review contains 3 figures, 9 tables, and 60 references.

      Key Words: Hypothyroidism, Thyrotoxicosis, Thyrotropin, celiac disease, vitiligo, pernicious anemia, Sjögren syndrome, Graves disease, Munchausen syndrome

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    • 16

      Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

      By Paul W. Ladenson, MD
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      Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

      • PAUL W. LADENSON, MDJohn Eager Howard Professor of Endocrinology & Metabolism, Professor of Medicine, Pathology, Oncology, Radiology & Radiological Sciences, and International Health, University Distinguished Service Professor, Director, Division of Endocrinology & Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland

      Thyroid disorders are the most common endocrine conditions encountered in clinical practice. Persons of either sex and any age can be affected, although almost all forms of thyroid disease are more frequent in women than in men, and many thyroid ailments increase in incidence with age. The presentation of thyroid conditions can range from clinically obvious to clinically silent. Their consequences can be widespread and serious, even life-threatening. With proper testing, the diagnosis and differential diagnosis can be established with certainty, and effective treatments can be instituted for almost all patients.

      This review contains 1 figure, 4 tables, and 30 references.

      Key Words: Hypothyroidism, Thyrotoxicosis, Thyrotropin, celiac disease, vitiligo, pernicious anemia, Sjögren syndrome, Graves disease, Munchausen syndrome

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    • 17

      Management of Dyslipidemia

      By John D. Brunzell, MD, FACP; R Alan Failor, MD
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      Management of Dyslipidemia

      • JOHN D. BRUNZELL, MD, FACPProfessor Emeritus, Active, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA
      • R ALAN FAILOR, MDClinical Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA

      Disorders of lipoprotein metabolism, in conjunction with the prevalence of high-fat diets, obesity, and physical inactivity, have resulted in an epidemic of atherosclerotic disease in the United States and other developed countries. The interaction of common genetic and acquired disorders of lipo­proteins with these adverse environmental factors leads to the premature development of atherosclerosis. In the United States, mortality from coronary artery disease (CAD), particularly in persons younger than 60 years, has been declining since 1970; however, atherosclerotic cardiovascular disease remains the most common cause of death among both men and women.

      This review contains 7 tables and 51 references.

      Keywords: Lipoprotein, Hepatic Lipase, Dyslipoproteinemias, hyper­lipoproteinemia, hypoalphalipoproteinemia

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    • 18

      Diagnosis of Dyslipidemia

      By John D. Brunzell, MD, FACP; R Alan Failor, MD
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      Diagnosis of Dyslipidemia

      • JOHN D. BRUNZELL, MD, FACPProfessor Emeritus, Active, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA
      • R ALAN FAILOR, MDClinical Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA

      Disorders of lipoprotein metabolism, in conjunction with the prevalence of high-fat diets, obesity, and physical inactivity, have resulted in an epidemic of atherosclerotic disease in the United States and other developed countries. The interaction of common genetic and acquired disorders of lipo­proteins with these adverse environmental factors leads to the premature development of atherosclerosis. In the United States, mortality from coronary artery disease (CAD), particularly in persons younger than 60 years, has been declining since 1970; however, atherosclerotic cardiovascular disease remains the most common cause of death among both men and women.

      This review contains 6 figures, 12 tables, and 44 references.

      Keywords: Lipoprotein, Hepatic Lipase, Dyslipoproteinemias, hyper­lipoproteinemia, hypoalphalipoproteinemia

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  • Ethics and Professionalism
  • Gastroenterology
    • 1

      Esophageal Disorder

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      Esophageal Disorder

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    • 2

      GI Bleeding

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      GI Bleeding

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    • 3

      Malabsorption and Maldigestion

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      Malabsorption and Maldigestion

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    • 4
    • 5

      GI Infections

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      GI Infections

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    • 6

      Diverticulosis and Diverticulitis (separate Appendicitis)

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      Diverticulosis and Diverticulitis (separate Appendicitis)

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    • 7

      Diseases of the Pancreas

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      Diseases of the Pancreas

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    • 8

      Gallstones and BT Disease

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      Gallstones and BT Disease

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    • 9

      Gastrointestinal Bleeding

      By Romeo Fairley, MD; Truman J. Milling Jr, MD
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      Gastrointestinal Bleeding

      • ROMEO FAIRLEY, MDResident, University of Texas, Austin Emergency Medicine Residency Program, Austin, TX
      • TRUMAN J. MILLING JR, MDDeputy Director of Clinical Research, Department of Emergency Medicine, University of Texas, Dell Medical School, Austin, TX

      Gastrointestinal bleeding occurs when a pathologic process such as ulceration, inflammation, or neoplasia leads to erosion of a blood vessel. Bleeding can occur in the upper gastrointestinal tract (50%) or the lower gastrointestinal tract (40%) or may be obscure (10%), meaning that no definitive source is identified. Gastrointestinal bleeding is common, with major bleeding leading to 1 million hospitalizations every year in the United States. This review details the pathophysiology of gastrointestinal bleeding and the stabilization and assessment, diagnosis, treatment, and disposition and outcomes of patients with gastrointestinal bleeding. Situations requiring special consideration are also discussed. Figures show how gastrointestinal bleeding occurs when a pathologic process causes erosion of the mucosa and exposes a submucosal blood vessel; an ulcer with a raised, red, variceal spot; a Mallory-Weiss tear; the formation of varices; vascular ectasia; treatment of esophageal varices with balloon tamponade; and a wireless capsule. Tables list the major causes of gastrointestinal bleeding, terms relating to gastrointestinal bleeding and their definitions, Blatchford score, substances that interfere with occult blood testing, clinical factors differentiating gastrointestinal bleeding placed in descending order of likelihood ratio, and a summary of American College of Radiology recommendations for angiography in nonvariceal gastrointestinal bleeding.

      This review contains 7 figures, 10 tables, and 102 references.

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    • 10

      Intra-abdominal and GI Cancers

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      Intra-abdominal and GI Cancers

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    • 11

      Inflammatory Bowel Disease (UC and Crohn’s)

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      Inflammatory Bowel Disease (UC and Crohn’s)

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    • 12
    • 13

      Ischemic Bowel

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      Ischemic Bowel

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    • 14

      Evaluation of Diarrhea (acute and Chronic)

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      Evaluation of Diarrhea (acute and Chronic)

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    • 15

      Acute Abdomen Including Appendicitis and Peritonitis

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      Acute Abdomen Including Appendicitis and Peritonitis

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    • 16

      Peptic Ulcer Diseases

      By Edward A Lew, MD, MPH
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      Peptic Ulcer Diseases

      • EDWARD A LEW, MD, MPHStaff Gastroenterologist, VA Boston Healthcare System, Brigham and Women’s Hospital, Assistant Professor of Medicine, Harvard Medical School, Boston, MA

      Peptic ulcers are defects or breaks in the inner lining of the gastrointestinal (GI) tract. Although the pathogenesis is multifactorial they tend to arise when there is an imbalance between protective and aggressive factors, such as when GI mucosal defense mechanisms are impaired in the presence of gastric acid and pepsin. Peptic ulcers extend through the mucosa and the muscularis mucosae, a thin layer of smooth muscle separating the mucosa from the deeper submucosa, muscularis propria, and serosa. Peptic ulcer disease affects up to 10% of men and 4% of women in Western countries at some time in their lives. 

      This chapter contains 6 Tables, 5 Figures and 50 references.

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    • 17

      Gastrointestinal Motility and Functional Disorders

      By Adil E Bharucha, MBBS, MD
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      Gastrointestinal Motility and Functional Disorders

      • ADIL E BHARUCHA, MBBS, MDProfessor of Medicine, Director, Motility Interest Group, Mayo Clinic, Rochester, MN

      Gastrointestinal (GI) motility disorders represent diseases characterized by abnormal, predominantly impaired, sometimes exaggerated, movement of contents through the GI tract due to neuromuscular dysfunctions in the absence of mucosal disease and mechanical causes of impaired passage. By contrast, functional GI disorders represent illnesses, defined only by GI symptoms, which occur in the absence of mucosal or structural abnormality or of known biochemical or metabolic disorders. The first section of this chapter discusses the enteric and extrinsic neural regulation of GI sensorimotor functions and normal GI motility in humans. Disorders such as gastroparesis (including diabetic gastroparesis, idiopathic gastroparesis, and postsurgical gastroparesis), dumping syndrome, intestinal pseudo-obstruction, small intestinal bacterial overgrowth, megacolon (including Hirschsprung disease, toxic megacolon, and colonic pseudo-obstruction), chronic constipation (including defecatory disorders, normal transit constipation, and slow transit constipation), functional dyspepsia, functional diarrhea and irritable bowel syndrome, and fecal incontinence are then discussed in depth. Tables present a comparison of GI motility and functional disorders, the causes of gastroparesis, the etiology of intestinal pseudo-obstruction and fecal incontinence, common medical conditions and medications associated with constipation, and the symptom severity scale in fecal incontinence. Illustrations, graphs, magnetic resonance images, and algorithms are provided.
      This chapter contains 10 highly rendered figures, 6 tables, 92 references, and 5 MCQs.

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    • 18

      Irritable Bowel Syndrome With Diarrhea

      By Judy Nee, MD; Jacqueline L. Wolf, MD
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      Irritable Bowel Syndrome With Diarrhea

      • JUDY NEE, MDInstructor in Medicine, Harvard Medical School, BIDMC, Beth Israel Deaconess Medical Center, Boston, MA
      • JACQUELINE L. WOLF, MDAssociate Professor of Medicine, Harvard Medical School, BIDMC, Beth Israel Deaconess Medical Center, Boston, MA

      Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal condition characterized by abdominal pain and alteration in bowel habits without an organic cause. One of the subcategories of this disorder is IBS with diarrhea (IBS-D). Clinically, patients who present with more than 3 months of abdominal pain or discomfort associated with an increase in stool frequency and/or loose stool form are defined as having IBS-D. This review addresses IBS-D, detailing the epidemiology, etiology and genetics, pathophysiology and pathogenesis, diagnosis, clinical manifestations and physical examination findings, differential diagnosis, treatment, emerging therapies, complications, and prognosis. Figures show potential mechanisms and pathophysiology of IBS, IBS-D suspected by clinical assessment and Rome III criteria, pharmacologic and nonpharmacologic treatment options, potential mechanisms of action of probiotics, and potential treatment modalities. Tables list the Rome criteria for IBS, alarm signs and symptoms suggestive of alternative diagnoses, IBS criteria, differential diagnosis of IBS-D, dietary advice options for IBS-D, and alternative and emerging therapies in IBS-D.

      This review contains 5 highly rendered figures, 6 tables, and 99 references. 

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    • 19

      Constipation

      By Charles H Knowles, MBBChir, PhD, FRCS
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      Constipation

      • CHARLES H KNOWLES, MBBCHIR, PHD, FRCS

      This review presents an overview of the management of constipation. The review addresses the diagnosis of primary and secondary forms and then discusses in greater detail the investigative workup and modern management of chronic constipation (primary). The review addresses what simple and more advanced investigations are relevant for determining pathophysiology and gives an overview of treatment options, including pharmacologic, behavioral, and surgical approaches for thus defined subgroups of patients (evacuation disorder, slow transit constipation).

      This review contains 3 figures, 6 tables, and 89 references.

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    • 20

      Gastrointestinal Bleeding

      By Romeo Fairley, MD; Truman J. Milling Jr, MD
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      Gastrointestinal Bleeding

      • ROMEO FAIRLEY, MDResident, University of Texas, Austin Emergency Medicine Residency Program, Austin, TX
      • TRUMAN J. MILLING JR, MDDeputy Director of Clinical Research, Department of Emergency Medicine, University of Texas, Dell Medical School, Austin, TX

      Gastrointestinal bleeding occurs when a pathologic process such as ulceration, inflammation, or neoplasia leads to erosion of a blood vessel. Bleeding can occur in the upper gastrointestinal tract (50%) or the lower gastrointestinal tract (40%) or may be obscure (10%), meaning that no definitive source is identified. Gastrointestinal bleeding is common, with major bleeding leading to 1 million hospitalizations every year in the United States. This review details the pathophysiology of gastrointestinal bleeding and the stabilization and assessment, diagnosis, treatment, and disposition and outcomes of patients with gastrointestinal bleeding. Situations requiring special consideration are also discussed. Figures show how gastrointestinal bleeding occurs when a pathologic process causes erosion of the mucosa and exposes a submucosal blood vessel; an ulcer with a raised, red, variceal spot; a Mallory-Weiss tear; the formation of varices; vascular ectasia; treatment of esophageal varices with balloon tamponade; and a wireless capsule. Tables list the major causes of gastrointestinal bleeding, terms relating to gastrointestinal bleeding and their definitions, Blatchford score, substances that interfere with occult blood testing, clinical factors differentiating gastrointestinal bleeding placed in descending order of likelihood ratio, and a summary of American College of Radiology recommendations for angiography in nonvariceal gastrointestinal bleeding.

      This review contains 7 highly rendered figures, 6 tables, and 140 references.

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    • 21

      Approach to the Patient With Abdominal Pain

      By Dana Sajed, MD
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      Approach to the Patient With Abdominal Pain

      • DANA SAJED, MDDirector of Ultrasound Education, Continuing Medical Education Director, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA

      Abdominal pain is the most common presenting complaint in the emergency department (ED), accounting for nearly 8% of ED visits. Although many chronic conditions may cause pain in the abdomen, acute abdominal pain, defined as undiagnosed pain present for less than 1 week, is of greatest concern to the emergency practitioner. For many reasons, acute abdominal pain is often diagnostically challenging. Abdominal pain may be due to numerous causes, including gastrointestinal, genitourinary, cardiovascular, pulmonary, and other sources. Symptoms may fluctuate or change in nature, and the quality of pain can be difficult for the patient to describe. Physical examination findings, although important, are variable and can even be misleading. Despite being such a common presenting complaint, misdiagnosis is not uncommon and results in a high percentage of medicolegal actions in both and adult and pediatric populations.

      Key words: abdominal computed tomography, abdominal pain, abdominal ultrasonography, pain management, point-of-care ultrasonography

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    • 22

      Gastrointestinal Tract Infections

      By Molly Paras, MD; Marcia B Goldberg, MD
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      Gastrointestinal Tract Infections

      • MOLLY PARAS, MDDivision of Infectious Diseases, Department of Medicine
      • MARCIA B GOLDBERG, MDAssociate Professor of Medicine, Division of Infectious Diseases, Harvard Medical School, and Physician, Massachusetts General Hospital, Boston, MA

      Gastrointestinal infections, which present with acute diarrhea, sometimes accompanied by vomiting, are an extremely common medical complaint, with an annual incidence of 0.6 illnesses per person. Transmission can occur from animals to person, from person to person, or by the ingestion of contaminated foodstuffs. In the United States, more than 90% of cases are caused by viruses, with norovirus being by far the most common. Common among bacterial causes of acute gastrointestinal infection are SalmonellaCampylobacterShigella, Shiga toxin–producing Escherichia coliVibrio, Yersinia, and Clostridium difficile. These infections are typically self-limited, but depending on the etiologic agent and characteristics of the host, antibiotic therapy may be indicated. Certain gastrointestinal infections are associated with significant complications, including reactive arthritis, Guillain-Barré syndrome, or septicemia.

      This review contains 4 figures, 7 tables, and 60 references.

      Key words: CampylobacterEscherichia coli, Guillain-Barré syndrome, reactive arthritis, Shiga toxin, ShigellaVibrioYersinia

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    • 23

      Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases

      By Dror S Shouval, MD, MMSc
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      Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases

      • DROR S SHOUVAL, MD, MMSCPediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

      Inflammatory bowel diseases (IBDs) are complex disorders that develop in genetically susceptible hosts due to dysregulated immune responses to microbial dysbiosis and environmental changes. Although in the vast majority of cases, the genetic contribution to development of these diseases is small, in rare cases, IBD develops directly as a result of deleterious mutations in the genes involved in immune and epithelial cell function. In these cases, intestinal inflammation is usually severe, which develops in most cases in the first years of life and occasionally is accompanied by recurrent or atypical infections. In this review, the approach to different monogenic disorders that cause IBD is discussed, including mutations in the IL-10 pathway, neutrophil defects, regulatory T-cell disorders, autoinflammatory conditions, epithelial cell diseases, and disorders affecting B- and T-lymphocyte dysfunction. Moreover, a multidisciplinary diagnostic approach is suggested, which highlights in which cases a monogenic disorder should be suspected.

      This review contains 3 figures, 5 tables, and 40 references.

      Key Words: inflammatory bowel disease, IL-10, chronic granulomatous disease, common variable immune deficiency, epithelial cells, genetics, immune cells, mucosal homeostasis, pathogenesis, very early–onset disease.

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  • Geriatric Medicine
    • 1

      Rehabilitation of the Geriatric Patients 

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      Rehabilitation of the Geriatric Patients 

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    • 2

      Other Considerations for Geriatric Populations Including Mistreatment, Polypharmacy, and Family Discussions 

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      Other Considerations for Geriatric Populations Including Mistreatment, Polypharmacy, and Family Discussions 

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    • 3

      Approach to the Geriatric Patient

      By Tia Kostas, MD; Mark Simone, MD; James L Rudolph, MD, SM
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      Approach to the Geriatric Patient

      • TIA KOSTAS, MDAssistant Professor of Medicine, Section of Geriatrics & Palliative Medicine, Department of Medicine, University of Chicago, Chicago, IL
      • MARK SIMONE, MDInstructor of Medicine, Harvard Medical School, Associate Program Director-Primary Care, Mount auburn Hospital Internal Medicine Residency, Director, Quality Improvement, Division of Geriatric Medicine, Department of Medicine, Mount Auburn Hospital, Cambridge, MA
      • JAMES L RUDOLPH, MD, SMAssociate Professor of Medicine, Harvard Medical School, Chief (Interim) Geriatrics and Palliative Care, Director, Boston, GRECC, VA Boston Healthcare System, Jamaica Plain, MA, Acting Clinical Chief, Associate Epidemiologist, Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA

      As of 2012, over one in eight Americans is over the age of 65, and this number is rising, particularly in the 85+ age group. This segment of the population has a rate of hospitalization three times higher than that for persons of all ages. General internists and family medicine physicians provide a large portion of care for this age group and should therefore be comfortable using a comprehensive approach to geriatric assessment. This review describes general considerations regarding geriatric care, including the process of taking a functional history and clinical implications of geriatric care. The geriatric assessment process is discussed in terms of physical, cognitive, social, and medical domains. The benefits of geriatric assessment in primary care, specialty care, and hospitalized patients are described. Tables outline activities of daily living, sensory changes with aging, major causes of visual impairment in the geriatric population, major neurocognitive disorder diagnostic criteria, medications to avoid or use with caution based on Beers criteria and Screening Tool of Older individuals’ Potentially inappropriate Prescriptions criteria, U.S. Preventive Services Task Force–recommended services relevant to older adults, and vaccinations in older adults. Figures illustrate the key vulnerabilities of older adults; outcomes linked to functional dependence; common disorders associated with cognitive concerns; domains of cognition and examples of impairment in theDiagnostic and Statistical Manual of Mental Disorders, fifth edition; the social and medical domains of geriatric assessment; barriers to medication adherence in older patients; and resources for medication appropriateness in older adults.

      This review contains 8 highly rendered figures, 8 tables, 110 references, and 5 MCQs.

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    • 4

      Assessment and Management of the Geriatric Patient

      By Tia Kostas, MD; Mark Simone, MD; James L Rudolph, MD, SM
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      Assessment and Management of the Geriatric Patient

      • TIA KOSTAS, MDAssistant Professor of Medicine, Section of Geriatrics & Palliative Medicine, Department of Medicine, University of Chicago, Chicago, IL
      • MARK SIMONE, MDInstructor of Medicine, Harvard Medical School, Associate Program Director-Primary Care, Mount auburn Hospital Internal Medicine Residency, Director, Quality Improvement, Division of Geriatric Medicine, Department of Medicine, Mount Auburn Hospital, Cambridge, MA
      • JAMES L RUDOLPH, MD, SMAssociate Professor of Medicine, Harvard Medical School, Chief (Interim) Geriatrics and Palliative Care, Director, Boston, GRECC, VA Boston Healthcare System, Jamaica Plain, MA, Acting Clinical Chief, Associate Epidemiologist, Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA

      Adults age 65 years and older make up an increasing percentage of the patient population. Physicians should recognize predisposing factors in their assessment of the geriatric patient, looking out for conditions such as homeostatic failure, multimorbidity, and functional disability, as well as clinical disorders that do not fit into discrete disease or organ system categories and are often described as geriatric syndrome. Through this and other strategies, such as evaluating patients at risk and implementing evidence-based therapy, physicians can substantially improve the well-being, functional independence, and quality of life of older adults. This review addresses the assessment and management of several geriatric syndromes, detailing cognitive impairment, falls and gait disturbances, malnutrition and weight loss, and pressure ulcers. Figures show types of dementia, nonpharmacologic interventions for cognitive impairment, a checklist for assessment of a delirious patient, nonpharmacologic management of delirium, the Timed Up and Go test, modifiable fall risk factors, and etiologies and management of weight loss. Tables list cognitive screens, cognition enhancers, delirium prevalence, confusion assessment method for diagnosis of delirium, differential features of delirium and dementia, common causes of unintentional weight loss in older adults, appetite enhancers and side effects, extrinsic forces involved in creating pressure ulcers, National Pressure Ulcer Advisory Panel staging system for pressure ulcers, specialty mattresses for pressure relief, and pressure ulcer dressings.

      This review contains 8 highly rendered figures, 11 tables, and 84 references.

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    • 5

      Assessment of the Geriatric Patient

      By Michelle Martinchek, MD
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      Assessment of the Geriatric Patient

      • MICHELLE MARTINCHEK, MD

      Geriatric syndromes are complex conditions that are common in older adults and often have multiple contributing factors. These syndromes do not fit into discrete disease or organ system categories like other conditions. As the population of older adults continues to grow, it is important that providers are equipped to assess older adults for these geriatric syndromes. These syndromes are associated with functional disability and other poor outcomes. Examples of these syndromes include cognitive impairment, delirium, falls, frailty, weight loss, and pressure ulcers. Understanding the epidemiology, pathogenesis, and predisposing factors may help providers identify patients at risk for these syndromes. Furthermore, a thorough assessment is key in the evaluation of these syndromes.

      This review contains 48 references, 4 figures, and 8 tables.

      Key Words: cognition, dementia, delirium, fall, frailty, gait, geriatric, malnutrition, pressure ulcer, weight loss

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  • Hematology
  • Hepatology
  • Human Genetics
    • 1

      Health Screening Considerations Based on Genetic Predispositions

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      Health Screening Considerations Based on Genetic Predispositions

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  • Infectious Disease
    • 1

      Upper Respiratory Tract Infections (including Bronchitis, Pharyngitis, Sinusitis, Otitis)

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      Upper Respiratory Tract Infections (including Bronchitis, Pharyngitis, Sinusitis, Otitis)

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    • 2

      Cellulitis (including Abscess and Mastitis)

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      Cellulitis (including Abscess and Mastitis)

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    • 3

      Infectious Colitis

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      Infectious Colitis

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    • 4
    • 5

      Septic Arthritis and Osteomyelitis

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      Septic Arthritis and Osteomyelitis

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    • 6

      Meningitis

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      Meningitis

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    • 7

      Sexually Transmitted Diseases

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      Sexually Transmitted Diseases

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    • 8

      Endocarditis

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      Endocarditis

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    • 9

      Lyme Disease

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      Lyme Disease

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    • 10

      Parasitic Infections

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      Parasitic Infections

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    • 11

      Fungal Infections

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      Fungal Infections

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    • 12

      Tuberculosis

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      Tuberculosis

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    • 13

      Zoonotic Infections

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      Zoonotic Infections

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    • 14

      HIV and AIDS

      By Daniel R. Kuritzkes, MD, FACP
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      HIV and AIDS

      • DANIEL R. KURITZKES, MD, FACP

      In the quarter-century since the first report of AIDS in the United States, HIV infection has spread throughout the population, disproportionately affecting black women, Hispanic women, and men who have sex with men. The prognosis for persons infected with HIV has improved dramatically with the introduction and evolution of highly active antiretroviral therapy (HAART). The underlying principle of HAART is that a combination of potent antiretrovirals, each of which requires different mutations in the HIV genome for resistance to develop, can suppress replication sufficiently to prevent mutation and the emergence of resistance. The prospect that currently available antiretroviral therapy (ART) regimens may suppress HIV replication indefinitely provides the hope that infected patients will have life expectancies similar to those of age-matched uninfected individuals. For these patients, HIV care has shifted from an emphasis on treatment and prevention of the complications of HIV disease itself to a focus on suppression of HIV replication and management of short- and long-term complications of HIV, ART toxicities, and aging. This chapter describes the epidemiology, pathophysiology and pathogenesis, prevention, diagnosis, and management of acute and chronic HIV infection and AIDS, with figures and tables illustrating each chapter section.


      This review contains 9 highly rendered figures, 22 tables, and 248 references.

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    • 15

      Urinary Tract Infections

      By Sigal Yawetz, MD
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      Urinary Tract Infections

      • SIGAL YAWETZ, MDAssociate Physician, Brigham and Women’s Hospital, Boston, MA; Assistant Professor of Medicine, Harvard Medical School, Boston, MA

      Urinary tract infection (UTI) is the most common bacterial infection, affecting women far more than men. Aerobic gram-negative bacteria are the most common uropathogens causing UTI, with Escherichia coli remaining the most predominant organism in complicated infections. UTI can result in a variety of infections and inflammations, from asymptomatic bacteriuria to typical symptomatic cystitis to acute pyelonephritis, as well as bacterial prostatitis in men.

      In general, antimicrobial therapy is warranted for any symptomatic infection of the urinary tract. However, new consensus treatment guidelines for uncomplicated UTI in women, set by the Infectious Diseases Society of America and the European Society for Microbiology of Infection Diseases in 2010, account for the increasing antimicrobial resistance of pathogens and focus on first-line empirical treatment regimens. To reduce the use of antibiotics, treatment and prevention of recurrent UTI may involve several strategies on varying levels of effectiveness; some of the more well-tested options include probiotics, antiseptics, and topical estrogen. Antimicrobial approaches should be reserved for women in whom these options prove to be ineffective.

      This review contains 7 highly rendered figures, 7 tables, and 120 references.

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    • 16

      Acute Pneumonia

      By John I Hogan, MD; Benjamin Davis, MD
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      Acute Pneumonia

      • JOHN I HOGAN, MD
      • BENJAMIN DAVIS, MD

      Acute pneumonia continues to represent a major source of morbidity, mortality, and healthcare expenditure in the U.S. It is imperative that clinicians at all levels of training have a firm understanding of this potentially deadly infection and its numerous complications. The current state of our diagnostic capabilities often dictates that clinicians will need to make important therapeutic decisions in patients presenting with acute pneumonia before identifying a culprit pathogen. Only after understanding the pathogenesis of pneumonia under different clinical circumstances can one devise rational empiric therapeutic regimens. In this practical review we offer a succinct description of the epidemiology and pathogenesis of acute pneumonia. We then proceed to discuss the evaluation and management of patients presenting with acute pneumonia with emphasis on the most valuable clinical trials and major guidelines that we use to inform our clinical decisions. Despite significant advances in the field of infectious disease over the past century, clinicians continue to recognize pneumonia, the infection of the pulmonary parenchyma, as a major source of morbidity and mortality. In this article we attempt to provide the general practitioner with a practical review of acute pneumonia and its complications. Prioritizing the needs of the general practitioner, we most thoroughly address community acquired pneumonia (CAP). Though we do not intend for this review to be completely comprehensive, in this article we also briefly discuss healthcare associated pneumonia (HCAP), hospital associated pneumonia (HAP), and ventilator associated pneumonia (VAP). Focusing much of our attention on the most important clinical trials and guidelines underpinning the diagnosis and management of this common problem, we hope that this publication will serve as a useful review to aid in clinical decision making.

      This review contains 45 references, 1 figure and 5 tables.

      Key Words: Pneumonia, viral pneumonia, bacterial pneumonia, community-acquired pneumonia, ventilator-associated pneumonia, VAP, healthcare-associated pneumonia, hospital-acquired pneumonia


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    • 17

      Bacterial Infections of the Adult Upper Respiratory Tract

      By Laura K Certain, MD, PhD; Miriam B Barshak, MD, PhD
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      Bacterial Infections of the Adult Upper Respiratory Tract

      • LAURA K CERTAIN, MD, PHDInstructor, Harvard Medical School, Assistant in Medicine, Massachusetts General Hospital, Boston, MA
      • MIRIAM B BARSHAK, MD, PHDAssistant Professor, Harvard Medical School, Attending Physician, Massachusetts General Hospital, Clinical Associate, Massachusetts Eye and Ear Infirmary, Boston, MA

      Upper respiratory tract infections are the most common maladies experienced by humankind.1 The majority are caused by respiratory viruses. A Dutch case-controlled study of primary care patients with acute respiratory tract infections found that viruses accounted for 58% of cases; rhinovirus was the most common (24%), followed by influenza virus type A (11%) and corona­viruses (7%). Group A streptococcus (GAS) was responsible for 11%, and 3% of patients had mixed infections. Potential pathogens were detected in 30% of control patients who were free of acute respiratory symptoms; rhinovirus was the most common.2 Given the increasing problem of antibiotic resistance and the increasing awareness of the importance of a healthy microbiome, antibiotic use for upper respiratory infections should be reserved for those patients with clear indications for treatment. A recent study of adult outpatient visits in the United States found that respiratory complaints accounted for 150 antibiotic prescriptions per 1,000 population annually, yet the expected “appropriate” rate would be 45.3 In other words, most antibiotic prescriptions for these complaints are unnecessary. Similarly, a study in the United Kingdom found that general practitioners prescribed antibiotics to about half of all patients presenting with an upper respiratory infection, even though most of these infections are viral.4

      This review contains 5 figures, 16 tables, and 82 references.

      Keywords: infection, airway, sinusitis, otitis media, otitis externa, pharyngitis, epiglottitis, abscess

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  • Interdisciplinary (and Preventative) Medicine
    • 1

      Exercise

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      Exercise

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    • 2

      Nutrition

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      Nutrition

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    • 3

      Prevention

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      Prevention

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    • 4

      Medical Evaluation of the Surgical Patient

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      Medical Evaluation of the Surgical Patient

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    • 5

      Drugs of Abuse

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      Drugs of Abuse

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    • 6

      Chronic Pain Management

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      Chronic Pain Management

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    • 7

      Physicians' Role in Curbing the Worst Drug Crisis in America: Prescription Opioid Abuse

      By Sairam Atluri, MD, FIPP; Gururau Sudarshan, MD, FRCA
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      Physicians' Role in Curbing the Worst Drug Crisis in America: Prescription Opioid Abuse

      • SAIRAM ATLURI, MD, FIPPDirector, Tristate Pain Management Institute, Cincinnati, OH
      • GURURAU SUDARSHAN, MD, FRCADirector, Cincinnati Pain Physicians, Cincinnati, OH

      Opioids have an important role in the management of acute, cancer, and chronic pain. However, their indiscriminate use in chronic pain has led, in part, to the epidemic of prescription drug abuse, resulting in a dramatic increase in morbidity and mortality in America. Most of this abuse originates from legitimate prescriptions by physicians. Prescribing opioids to chronic pain patients while restricting them to those who abuse them is very challenging, and physicians seek appropriate and unbiased prescribing guidelines. Our review, based on analysis of the available literature, focuses on striking a balance between overprescribing and underprescribing. The core concept of this strategy relies in using screening tools to identify patients who are at high risk for opioid abuse along with diligent monitoring using prescription monitoring programs and urine drug screens, while also limiting opioid doses. Hopefully, using these principles, physicians can more confidently prescribe opioids to those who would benefit from these powerful drugs and at the same time keep opioids away from those who could potentially be harmed.

      Key Words: abuse, addiction, chronic pain, dose limitation, misuse, monitoring, opioids, overdose, screening

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  • Integrative Medicine
  • Nephrology and Urology
    • 1

      Electrolyte Disturbances

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      Electrolyte Disturbances

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    • 2

      Acute Kidney Injury

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      Acute Kidney Injury

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    • 3

      Pharmacologic Approach to Renal Insufficiency

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      Pharmacologic Approach to Renal Insufficiency

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    • 4

      Vascular Diseases of the Kidney

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      Vascular Diseases of the Kidney

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    • 5
    • 6

      Urinalysis

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      Urinalysis

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    • 7

      Incontinence and Overactive Bladder

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      Incontinence and Overactive Bladder

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    • 8

      Chronic Kidney Failure and Dialysis

      By Raghu V Durvasula, MD; Jonathan Himmelfarb, MD
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      Chronic Kidney Failure and Dialysis

      • RAGHU V DURVASULA, MDAssistant Professor of Medicine, Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, WA
      • JONATHAN HIMMELFARB, MDDepartment of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, WA

      Chronic kidney disease (CKD) is a clinical syndrome arising from progressive kidney injury, formerly known as chronic renal failure, chronic renal disease, and chronic renal insufficiency. It is classified into five stages based primarily on glomerular filtration rate (GFR). This article discusses the epidemiology of CKD and end-stage renal disease (ESRD), as well as etiology and genetics, pathophysiology, and pathogenesis. The section on diagnosis looks at clinical manifestations and physical findings, laboratory (and other) tests, imaging studies, and biopsy. A short section on differential diagnosis is followed by a discussion of treatment, including hemodialysis and peritoneal dialysis. Long-term complications of patients on dialysis include cardiovascular disease, renal osteodystrophy, dialysis-related amyloidosis, and acquired cystic disease (renal cell carcinoma). The final section addresses prognosis and socioeconomic burden. Figures include the classification system for CKD, prevalence of CKD in the United States, rising prevalence, risk of, and leading causes of ESRD in the United States, plus the changing prevalence of ESRD over time, clinical manifestations of uremia, and an overview of hemodialysis circuit. Tables look at the burden of CKD relative to other chronic disorders, the specific hereditary causes of kidney disease, and situations when serum creatinine does not accurately predict GFR. Other tables list equations for estimating GFR, the causes of CKD without shrunken kidneys, and clinical features distinguishing chronic kidney disease from acute kidney injury. ESRD and indications for initiation of dialysis are presented, as well as typical composition of dialysate and reasons for failure of peritoneal dialysis. This chapter contains 71 references.

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    • 9

      Nephrolithiasis

      By José Luiz Nishiura, MD, PhD; Ita Pfeferman Heilberg, MD, PhD
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      Nephrolithiasis

      • JOSÉ LUIZ NISHIURA, MD, PHDAssociate Researcher, Nephrology Division, Federal University of São Paulo, São Paulo, Brazil.
      • ITA PFEFERMAN HEILBERG, MD, PHDAssociate Professor, Nephrology Division, Federal University of São Paulo, São Paulo, Brazil.

      Nephrolithiasis is a highly prevalent condition, but its incidence varies depending on race, gender, and geographic location. Approximately half of patients form at least one recurrent stone within 10 years of the first episode. Renal stones are usually composed of calcium salts (calcium oxalate monohydrate or dihydrate, calcium phosphate), uric acid, or, less frequently, cystine and struvite (magnesium, ammonium, and phosphate). Calcium oxalate stones, the most commonly encountered ones, may result from urinary calcium oxalate precipitation on the Randall plaque, which is a hydroxyapatite deposit in the interstitium of the kidney medulla. Uric acid nephrolithiasis, which is common among patients with metabolic syndrome or diabetes mellitus, is caused by an excessively acidic urinary pH as a renal manifestation of insulin resistance. The medical evaluation of the kidney stone patient must be focused on identifying anatomic abnormalities of the urinary tract, associated systemic diseases, use of lithogenic drugs or supplements, and, mostly, urinary risk factors such as low urine volume, hypercalciuria, hyperuricosuria, hypocitraturia, hyperoxaluria, and abnormalities in urine pH that can be affected by dietary habits, environmental factors, and genetic traits. Metabolic evaluation requires a urinalysis, stone analysis (if available), serum chemistry, and urinary parameters, preferably obtained by two nonconsecutive 24-hour urine collections under a random diet. Targeted medication and dietary advice are effective to reduce the risk of recurrence. Clinical, radiologic, and laboratory follow-ups are needed to prevent stone growth and new stone formation, to assess treatment adherence or effectiveness to dietary recommendations, and to allow adjustment of pharmacologic treatment.

      This review contains 5 highly rendered figure, 3 tables, and 105 references.

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    • 10

      Management of Chronic Kidney Disease and Its Complications

      By Ajay K Singh, MBBS, FRCP (UK), MBA; Joshua S. Hundert, MD
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      Management of Chronic Kidney Disease and Its Complications

      • AJAY K SINGH, MBBS, FRCP (UK), MBAAssociate Professor of Medicine, Associate Dean for Global Education and Continuing Education, Harvard Medical School, Director, Continuing Medical Education, Department of Medicine and Renal Division, Brigham and Women’s Hospital, Boston, MA
      • JOSHUA S. HUNDERT, MDClinical Fellow, Department of Medicine, Division of Nephrology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

      Management of early renal failure helps in the reduction or prevention of end-stage renal disease. The monitoring of renal function is discussed, and the chapter includes a table that shows commonly used methods for monitoring. Risk factors for chronic renal failure include stroke and cardiac disease. Risk factors for renal disease progression are diabetes mellitus, hypertension, proteinuria, smoking, protein intake, and hyperlipidemia. Complications of chronic renal failure that are addressed include sodium and water imbalance, potassium imbalance, acidosis, calcium and phosphorus imbalance, and anemia. There is also a section that discusses the case for early referral to a nephrologist. Tables present the equations used to estimate the glomerular filtration rate (GFR); stages of chronic kidney disease and the appropriate steps in their management; risk factors for chronic kidney disease in which the testing of proteinuria and estimation of GFR are indicated; appropriate diet for patients who have chronic kidney disease; and guidelines for diagnosing and treating anemia resulting from chronic kidney disease. An algorithm outlines the steps in management of calcium and phosphate in patients with kidney disease.

      This review contains 3 figures, 10 tables and 50 references

      Key Words End-stage renal disease, chronic kidney disease, glomerular filtration rate, Modification of Diet in Renal Disease, Proteinuric renal disease, Hyperuricemia

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  • Neurology
    • 1
    • 2

      Headaches 

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      Headaches 

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    • 3

      Non-diabetic Neuropathy

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      Non-diabetic Neuropathy

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    • 4

      Pain Syndromes

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      Pain Syndromes

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    • 5

      Dementia (including Alzheimer's Disease)

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      Dementia (including Alzheimer's Disease)

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    • 6

      Neuromuscular Diseases

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      Neuromuscular Diseases

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    • 7
    • 8

      Epilepsy

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      Epilepsy

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    • 9

      Evaluation of Tremors

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      Evaluation of Tremors

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    • 10

      Parkinsonism and Related Disorders

      By Elizabeth J. Slow, MD, PhD; Anthony E. Lang, MD
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      Parkinsonism and Related Disorders

      • ELIZABETH J. SLOW, MD, PHDAssistant Professor, Morton and Gloria Shulman Movement Disorders Clinic and The Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University of Toronto, Toronto, ON
      • ANTHONY E. LANG, MDProfessor, Morton and Gloria Shulman Movement Disorders Clinic and The Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital, University of Toronto, Toronto, ON

      Parkinsonism describes the core clinical criteria of tremor, bradykinesia, rigidity, and postural instability. There is a large differential diagnosis, but the most common cause of parkinsonism is due to Parkinson disease. This review details the epidemiology, etiology/genetics, pathogenesis, diagnosis and differential diagnosis, management, and prognosis of Parkinson disease, dementia with Lewy bodies, progressive supranuclear palsy, corticobasal degeneration, vascular parkinsonism, normal pressure hydrocephalus, and drug-induced parkinsonism. Figures show Parkinson disease features; timeline of the clinical course of Parkinson disease; summary of the diagnosis, management, and prognosis of Parkinson disease; an algorithm for the treatment of tremor-predominant Parkinson disease; an algorithm for the treatment of Parkinson disease with predominance of bradykinesia and rigidity; magnetic resonance imaging changes in multiple system atrophy; magnetic resonance imaging changes in progressive supranuclear palsy; and enlarged ventricles associated with normal pressure hydrocephalus. Tables list differential diagnosis of parkinsonism; clues to alternative, non-Parkinson disease causes of parkinsonism (i.e., red flags of parkinsonism); distinguishing other diseases causing parkinsonism from Parkinson disease; treatment of motor symptoms of Parkinson disease; peripheral and central side effects of dopaminergic (dopamine agonist and levodopa) therapy; and treatment of nonmotor symptoms of Parkinson disease.

      This review contains 8 highly rendered figures, 6 tables, and 88 references.

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    • 11

      Dizziness

      By Kevin A. Kerber, MD, MS; Robert W. Baloh, MD
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      Dizziness

      • KEVIN A. KERBER, MD, MSAssistant Professor, Department of Neurology, University of Michigan, Ann Arbor, MI
      • ROBERT W. BALOH, MDProfessor, Departments of Neurology and Surgery (Head and Neck), UCLA Medical Center, Reed Neurological Research Center, Los Angeles, CA

      Dizziness is the quintessential symptom presentation in all of clinical medicine. It is a common reason that patients present to a physician. This chapter provides background information about the vestibular system, then reviews key aspects of history-taking and examination of the patient, then discusses specific disorders and common presentation types. Throughout the chapter the focus is on neurologic and vestibular disorders. Normal vestibular anatomy and physiology are discussed, followed by recommendations for history-taking and the physical examination. Specific disorders that cause dizziness are explored, along with common causes of non-specific dizziness. Common presentations are discussed, including acute severe dizziness, recurrent attacks, and recurrent positional vertigo. Finally, the chapter looks at laboratory investigations in diagnosis and management. Figures include population prevalence of dizziness symptoms, the anatomy of inner structures, primary afferent vestibular nerve activity, the head thrust test, the Dix-Hallpike maneuver, the supine positional test, the canalith repositioning procedure, and the barbecue roll maneuver. Tables list physiologic properties and clinical features of the components of the peripheral vestibular system, information to be acquired from history of the present illness, common symptoms patients report as dizziness, examination components, distinguishing among common peripheral and central vertigo syndromes, common causes of nonspecific dizziness, types of dizziness presentations, relevant imaging abnormalities on neuroimaging studies, vestibular testing components, and medical therapy for symptomatic dizziness.

      This review contains 8 highly rendered figures, 11 tables, and 69 references.

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    • 12

      Acute Ischemic Stroke and Transient Ischemic Attack

      By Lauren M. Nentwich, MD
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      Acute Ischemic Stroke and Transient Ischemic Attack

      • LAUREN M. NENTWICH, MDAssistant Professor, Department of Emergency Medicine, Boston University School of Medicine, Boston, MA

      Stroke is a sudden neurologic deficit attributed to an acute focal injury of the central nervous system (CNS) by a vascular cause, including either ischemia (87%) or hemorrhage (13%). Specifically, acute ischemic stroke (AIS) is an episode of neurologic dysfunction caused by focal cerebral, spinal, or retinal infarction, where infarction is defined as pathologic, imaging, clinical, or other objective evidence of focal ischemic cell death and injury in a defined vascular distribution. Conversely, a transient ischemic attack (TIA) is defined as a transient episode of neurologic dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute infarction. A TIA is not a separate entity from AIS, but rather both AIS and TIA are on the spectrum of serious conditions caused by CNS ischemia. This review covers the pathophysiology, stabilization and assessment, diagnosis and treatment, and  disposition and outcomes of AIS and TIA. Figures show potential sources of cardioembolism, cerebrovascular anatomy and common sites of atherosclerosis, early computed tomographic (CT) findings in AIS and noncontrast head CT scan of a right putamenal intracerebral hemorrhage, magnetic resonance image (MRI) showing perfusion-diffusion mismatch in AIS, and intra-arterial thrombolysis for AIS. Tables list clinical features of the major cerebrovascular occlusive syndromes, ABCD score, time goals in the emergency department evaluation of patients presenting with suspected AIS, differential diagnosis of AIS (i.e., stroke mimics), National Institutes of Health stroke scale, multimodal CT in AIS, multimodal MRI in AIS, and indications and contraindications for intravenous recombinant tissue plasminogen activator treatment in AIS.

      Key words: acute ischemic stroke, atheroembolism, cardioembolism, stroke, transient ischemic attack

       

      This review contains 5 highly rendered figures, 8 tables, and 100 references.

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    • 13

      Intracerebral Hemorrhage

      By Natalie P. Kreitzer, MD; Opeolu Adeoye, MD, MS
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      Intracerebral Hemorrhage

      • NATALIE P. KREITZER, MDNeurocritical Care Fellow in Training, Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH
      • OPEOLU ADEOYE, MD, MSAssociate Professor of Emergency Medicine and Neurocritical Care, University of Cincinnati, Cincinnati, OH

      Intracerebral hemorrhage can be classified as either secondary (due to trauma, vascular malformations, aneurysms, tumors, or hemorrhagic transformation of ischemic stroke) or primary (without a clear secondary cause). Intracerebral hemorrhage is a neurologic emergency, and leads to significant death and disability each year; care should be expedited and emergency departments should be equipped to appropriately care for and manage these patients. This review covers the risk factors, natural history, pathophysiology, stabilization and assessment, diagnosis and treatment, and disposition and outcomes for patients with intracerebral hemorrhage. Figures show head computed tomographic scans demonstrating a left basal ganglia intracerebral hemorrhage, and an algorithm of management of intracerebral hemorrhage in the emergency department. Tables list some common causes of intracerebral hemorrhage, Boston criteria for diagnosis of cerebral amyloid angiopathy, mechanism of action of common anticoagulants, and suggested reversal agents.


      This review contains 2 figures, 6 tables, and 59 references.

      Key words: Intracerebral hemorrhage; intracranial hemorrhage; intraparenchymal hemorrhage; hemorrhagic stroke; hypertensive hemorrhage; spontaneous intracerebral hemorrhage; ICH; cerebral bleeds


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    • 14

      Coma and Disorders of Consciousness

      By Jonathan A. Edlow, MD, FACEP; Nicole M Dubosh, MD
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      Coma and Disorders of Consciousness

      • JONATHAN A. EDLOW, MD, FACEPVice-Chairman of Emergency Medicine, Beth Israel Deaconess Medical Center, Professor of Medicine and Emergency Medicine, Harvard Medical School, Boston, MA
      • NICOLE M DUBOSH, MD

      There are many causes of disorders of consciousness, including toxic/metabolic, infectious, and traumatic disorders, as well as other causes that may be more difficult to diagnose. Following stabilization, a thorough history taking involving discussion with family members, witnesses, friends, or police can often help disclose the likely cause of coma, although the resulting information may be limited. In the emergency department, physicians should be extremely cautious about making an early prognosis or diagnosis of brain death because all relevant information may not yet be available. This review examines the pathophysiology, stabilization and assessment, diagnosis and treatment, prognosis, and disposition and outcomes for coma and disorders of consciousness. Figures show anatomic structures and dorsal and ventral pathways involved with the maintenance of consciousness, the Full Outline of Unresponsiveness (FOUR) scale, and the spectrum of pupil abnormalities and causes. Tables list the Glasgow Coma Scale, blood gas abnormalities due to toxins, and a computed tomography checklist for comatose patients. 

      This review contains 3 figures, 5 tables, and 62 references.

      Keywords: coma, altered level of consciousness, reticular activating system, basilar artery stroke, posterior circulation stroke, stupor, brain herniation, brainstem compression, non-convulsive status epilepticus


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    • 15

      Headache

      By Benjamin W Friedman, MD, MS
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      Headache

      • BENJAMIN W FRIEDMAN, MD, MSProfessor of Emergency Medicine, Department of Emergency Medicine,Albert Einstein College of Medicine, Montefi ore Medical Center, Bronx, NY

      Headaches are one of the most common complaints of patients seen by emergency physicians. They can be classified as primary headaches, which have no identifiable underlying cause, and secondary headaches, which are classified according to their cause. The majority of headaches are benign in origin, and most patients with headache can be treated successfully in the emergency department and discharged home; however, some have potentially life-threatening causes, and consideration of a broad differential diagnosis for all patients is essential. This review covers the primary headache disorders, pathophysiology, stabilization and assessment, diagnosis and treatment, and disposition and outcomes. The figure shows areas of the brain sensitive to pain. Tables review differential diagnosis of headache, International Headache Society primary headache criteria, clinical characteristics of secondary headaches, high-risk clinical characteristics among patients with a headache peaking in intensity within 1 hour, drugs associated with headache, and parenteral treatment of acute migraine.

      This review contains 1 figure, 9 tables, and 58 references.


      Key words: migraine, calcitonin gene related peptide, greater occipital nerve block, venous sinus thrombosis, reversible cerebral vasoconstriction syndrome, Ottawa, subarachnoid, cluster headache, trigeminal autonomic cephalalgias, post-traumatic headache

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    • 16

      Principles of Neurologic Ethics

      By Matthew S. Siket, MD; Jay M. Baruch, MD
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      Principles of Neurologic Ethics

      • MATTHEW S. SIKET, MDAssistant Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI
      • JAY M. BARUCH, MDAssociate Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI

      Neuroethics refers to the branch of applied bioethics pertaining to the neurosciences and emerging technologies that impact our ability to understand or enhance a human mind. In the setting of emergency medicine, the clinician will encounter neuroethical dilemmas pertaining to the acutely brain injured or impaired; similar to other ethical decisions encountered in emergency medicine, such neuroethical dilemmas are often complicated by insufficient information regarding the patient’s wishes and preferences and a short time frame in which to obtain this information. This review examines the basis of neuroethics in emergency medicine; neuroethical inquiry; the neuroscience of ethics and intuition; issues regarding autonomy, informed consent, paternalism, and persuasion; shared decision making; situations in which decision-making capacity is in question; beneficence/nonmaleficence; incidental findings and their implications; risk predictions; and issues of justice. The figure shows the use of tissue plasminogen activator (t-PA) for cerebral ischemia within 3 hours of onset and changes in outcome due to treatment. Tables list common ethical theories, virtues/values of an acute care provider, components of informed consent discussion unique to t-PA in acute ischemic stroke, models of the physician-patient relationship, eight ways to promote effective shared decision making, components of capacity assessment, and emergency department assessment of futility.

      This review contains 1 figure, 9 tables, and 90 references.

      Keywords: Ethics, autonomy, shared decision-making, moral dilemmas, framing, decision-making capacity, beneficence and nonmaleficence

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    • 17

      Epilepsy and Related Disorders

      By Barbara Dworetzky, MD; Jong Woo Lee, MD, PhD
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      Epilepsy and Related Disorders

      • BARBARA DWORETZKY, MDAssociate Professor of Neurology, Harvard Medical School, Chief, Division of Epilepsy, EEG, and Sleep Neurology, Director, The Edward B. Bromfield Epilepsy Program, Brigham and Women’s Hospital, Boston, MA
      • JONG WOO LEE, MD, PHDAssistant Professor of Neurology, Harvard Medical School, Director, ICU EEG Monitoring, The Edward B. Bromfield Epilepsy Program, Brigham and Women’s Hospital, Boston, MA

      Epilepsy is a chronic disorder of the brain characterized by recurrent unprovoked seizures. A seizure is a sudden change in behavior that is accompanied by electrical discharges in the brain. Many patients presenting with a first-ever seizure are surprised to find that it is a very common event. A reversible or avoidable seizure precipitant, such as alcohol, argues against underlying epilepsy and therefore against treatment with medication. This chapter discusses the epidemiology, etiology, and classification of epilepsy and provides detailed descriptions of neonatal syndromes, syndromes of infancy and early childhood, and syndromes of late childhood and adolescence. The pathophysiology, diagnosis, and differential diagnosis are described, as are syncope, migraine, and psychogenic nonepileptic seizures. Two case histories are provided, as are sections on treatment (polytherapy, brand-name versus generic drugs, surgery, stimulation therapy, dietary treatments), complications of epilepsy and related disorders, prognosis, and quality measures. Special topics discussed are women?s issues and the elderly. Figures illustrate a left midtemporal epileptic discharge, wave activity during drowsiness, cortical dysplasias, convulsive syncope, rhythmic theta activity, right hippocamal sclerosis, and right temporal hypometabolism. Tables describe international classifications of epileptic seizures and of epilepsies, epilepsy syndromes and related seizure disorders, differential diagnosis of seizure, differentiating epileptic versus nonepileptic seizures, antiepileptic drugs, status epilepticus protocol for treatment, when to consider referral to a specialist, and quality measures in epilepsy. 

      This review contains 7 figures, 10 tables, and 33 references.

      Key Words: Seizures, focal (partial)seizure, generalized seizures, Myoclonic seizures, Atonic seizures, Concurrent electromyographyTonic-clonic (grand mal) seizures

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  • Oncology
    • 1

      Head/neck Cancer

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      Head/neck Cancer

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    • 2

      Lung Cancer

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      Lung Cancer

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    • 3

      Pancreatic, Gastric, and Other GI Cancers

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      Pancreatic, Gastric, and Other GI Cancers

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    • 4

      Gyn Cancer

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      Gyn Cancer

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    • 5

      Prostate Cancer

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      Prostate Cancer

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    • 6

      Bladder/gu Cancer

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      Bladder/gu Cancer

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    • 7

      Sarcomas of the Soft Tissue and Bone

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      Sarcomas of the Soft Tissue and Bone

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    • 8

      Colorectal Cancer

      By Cathy Eng, MD, FACP
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      Colorectal Cancer

      • CATHY ENG, MD, FACPAssociate Professor, Associate Director of the Colorectal Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX

      Colorectal cancer is the third most common cancer and the second leading cause of cancer death in the United States. Although environmental factors, including diet and lifestyle, clearly play a role in the etiology of colorectal cancer, as many as 25% of patients with colorectal cancer have a family history of the disease, which suggests the involvement of a genetic factor. Inherited colon cancers can be divided into two main types: the well-studied but rare familial adenomatous polyposis (FAP) syndrome, and the increasingly well-characterized, more common hereditary nonpolyposis colorectal cancer (HNPCC, a.k.a. Lynch Syndrome). The prevention, screening, diagnosis, and treatment of cancers of the colon and rectum are covered in this chapter. Figures illustrate various forms of adenomatous polyps, the tumor, node, metastasis (TNM) staging system for colorectal cancer, and the five-year survival rate in patients with colorectal carcinoma. Tables describe risk factors; possible chemopreventive agents; evidence supporting the effectiveness of screening tests; features and usage issues with different fecal occult blood tests; recommendations for early detection, screening, and surveillance for patients at different levels of risk; colorectal cancer staging systems; indicators of poor prognosis; and chemotherapeutic and biologic agents in the treatment of colorectal cancer. This chapter contains 197 references.

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    • 9

      Breast Cancer

      By Nancy E Davidson, MD
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      Breast Cancer

      • NANCY E DAVIDSON, MDDirector, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Hillman Professor of Oncology, University of Pittsburgh, Pittsburgh, PA

      Invasive breast cancer, the most common nonskin cancer in women in the United States, will be diagnosed in 266,120 In 2018, along with 63,960 new cases of non-invasive (in situ) breast cancer. Incidence and mortality reached a plateau and appear to be dropping in both the United States and parts of western Europe. This decline has been attributed to several factors, such as early detection through the use of screening mammography and appropriate use of systemic adjuvant therapy, as well as decreased use of hormone replacement therapy. However, the global burden of breast cancer remains great, and global breast cancer incidence increased from 641,000 in 1980 to 1,643,000 in 2010, an annual rate of increase of 3.1%. This chapter examines the etiology, epidemiology, prevention, screening, staging, and prognosis of breast cancer. The diagnoses and treatments of the four stages of breast cancer are also included. Figures include algorithms used for the systemic treatment of stage IV breast cancer and hormone therapy for women with stage IV breast cancer. Tables describe selected outcomes from the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 and P-2 chemoprevention trials, tamoxifen chemoprevention trials for breast cancer, the TNM staging system and stage groupings for breast cancer, some commonly used adjuvant chemotherapy regimens, an algorithm for suggested treatment for patients with operable breast cancer from the 2011 St. Gallen consensus conference, guidelines for surveillance of asymptomatic early breast cancer survivors from the American Society of Clinical Oncology, and newer agents for metastatic breast cancer commercially available in the United States.

      This review contains 2 highly rendered figures, 8 tables, and 108 references.

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    • 10

      Cervical Cancer Prevention and Screening

      By Andrew Quinn, MD; Carolyn D Runowicz, MD
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      Cervical Cancer Prevention and Screening

      • ANDREW QUINN, MDResident, PGY-1, Department of Obstetrics and Gynecology, New York Hospital, New York, NY
      • CAROLYN D RUNOWICZ, MDExecutive Associate Dean for Academic Affairs, Professor of Obstetrics and Gynecology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL

      With the advent of HPV DNA testing and the availability of HPV vaccinations, the recommendations and rationale for screening and prevention of cervical cancer and its precursors have undergone revision, reflecting this new knowledge and understanding of cervical intra-epithelial neoplasia and the role of HPV. This review incorporates the new guidelines and rationale for current screening guidelines for cervical cancer and in the management of patients with atypical or unsatisfactory cervical cytology.

      This review contains 4 tables and 64 references

      Key words: Cervical cancer, Gynecological cancer, HPV, HPV testing, HPV vaccine, Pap smear, HPV DNA, Human papillomavirus

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    • 11

      Late Stage Prostate Cancer

      By Karthik Giridhar, MD; Manish Kohli, MD
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      Late Stage Prostate Cancer

      • KARTHIK GIRIDHAR, MDOncology Fellow, Mayo Clinic, Division of Medical Oncology, Rochester, MN
      • MANISH KOHLI, MDProfessor of Oncology, Mayo Clinic, Division of Medical Oncology, Rochester, MN

      Prostate cancer remains the second leading cause of cancer death in men and encapsulates a wide spectrum of disease. This review describes recent advances in genomic sciences and summarizes the impact of emerging molecular profiling–based clinical applications in the diagnosis and management of early and advanced prostate cancer. It addresses the controversial guidelines surrounding prostate-specific antigen–based screening for prostate cancer and summarizes the recommendations from six different agencies. This review highlights landmark clinical trials in metastatic prostate cancer, focusing on developments within the last 5 years. It also summarizes the rationale for earlier use of chemotherapy for newly diagnosed prostate cancer (chemohormonal therapy) and gives an overview of ongoing research into the development of novel genome-based therapeutics.

      This review contains 4 figures, 7 tables, and 53 references.

      Key words: castration resistant, molecular profiling, prostate cancer, screening guidelines, treatment options

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  • Palliative Medicine
    • 1

      Principles and Practice of Palliative Care 

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      Principles and Practice of Palliative Care 

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    • 2

      Symptom Management in Palliative Medicine

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      Symptom Management in Palliative Medicine

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    • 3

      Management of Psychosocial Issues in Terminal Illness

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      Management of Psychosocial Issues in Terminal Illness

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    • 4

      Communication of Bad News

      By Paul K Mohabir, MD; Preethi Balakrishnan, MD
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      Communication of Bad News

      • PAUL K MOHABIR, MDClinical Professor, Pulmonary and Critical Care Medicine
      • PREETHI BALAKRISHNAN, MDCritical Care Medicine Fellow, Stanford Hospital, Stanford, CA

      Delivering bad news is a critical part of the patient-physician relationship. Historically, physicians have withheld or incompletely related the diagnosis and prognosis of a patient’s disease. However, the trajectory of medical practice and patient expectations mandates a change in communicating bad news. Poor communication of bad news also affects physician job satisfaction and increases burnout. Empathy is crucial to communicating bad news well. It is a very complex emotion that requires the physician to identify the patient’s reaction to the news being delivered and to react to the patient in a supportive manner. Patients do not find it helpful when the physician underplays the bad part of the news. Emerging research shows that patients prefer pairing of bad news with hope to provide anchors in the overwhelming conversation but not to take away from the gravity of the news. Family and friends can help ameliorate or, unfortunately, augment patient anxiety. Physicians have to be cognizant of the dynamics family and friends bring to the interaction as well. A patient-centered approach—a combination of evidence-based medicine and patient goal-oriented medicine—to delivering bad news is most likely to benefit the patient-physician relationship and decision-making process. The SPIKES and the Expanded Four Habits Model can be used as guidelines for communicating bad news.

      This review contains 1 figure and 38 references.

      Key words: communicating bad news, empathy, Expanded Four Habits Model, patient-centered care, SPIKES

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  • Psychiatry
    • 1
    • 2

      Eating Disorders

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      Eating Disorders

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    • 3

      Adjustment Disorders 

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      Adjustment Disorders 

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    • 4

      Male Sexual Dysfunction

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      Male Sexual Dysfunction

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    • 5
    • 6

      Sleep Disorders 

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      Sleep Disorders 

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    • 7

      Acute Psychosis and Delirium

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      Acute Psychosis and Delirium

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    • 8

      Overview of Anxiety Disorders

      By Jon E Grant, JD, MD, MPH
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      Overview of Anxiety Disorders

      • JON E GRANT, JD, MD, MPH

      Anxiety disorders are the most common psychiatric disorders among adults in the United States. Although anxiety disorders generally result in significant psychosocial impairment, most adults do not seek treatment until many years after the onset of the anxiety disorder. The treatment literature for anxiety disorder has grown tremendously since the 1980s, and both psychotherapy and medications may prove beneficial for people with anxiety disorders. This review presents a general overview of the anxiety disorders.

      This review contains 7 tables, and 33 references.

      Key words: agoraphobia, anxiety disorder, generalized anxiety disorder, panic disorder, separation anxiety disorder, social anxiety disorder, specific phobia, treatment of anxiety

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    • 9

      Overview of Posttraumatic Stress Disorder

      By Carol North, MD, MPE; Dana Downs, MA, MSW
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      Overview of Posttraumatic Stress Disorder

      • CAROL NORTH, MD, MPEMedical Director, The Altshuler Center for Education & Research at Metrocare Services, The Nancy and Ray L. Hunt Chair in Crisis Psychiatry and Professor of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX
      • DANA DOWNS, MA, MSWClinical Research Manager (Retired), Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX

      Posttraumatic stress disorder (PTSD) is a psychiatric disorder that may follow exposure to trauma. The experience of trauma has potential personal implications. Some individuals develop PTSD after trauma; others may be more resilient, experiencing distress but not succumbing to psychopathology; and yet others may emerge from the experience with new strength and direction.

      This review contains 1 figure, 5 tables, and 46 references

      Keyword: Posttraumatic stress disorder, transcranial magnetic stimulation (TMS), deep brain stimulation, vagal nerve stimulation, transcranial direct current stimulation, Diagnostic and Statistical Manual of Mental Disorders, hypothalamic-pituitary-adrenal (HPA) axis

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    • 10

      Management of Somatic Symptoms

      By Andreas Schröder, MD, PhD; Joel E Dimsdale, MD
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      Management of Somatic Symptoms

      • ANDREAS SCHRÖDER, MD, PHDConsultant in Psychiatry, The Research Clinic for Functional Disorders, Aarhus University Hospital, Aarhus, Denmark
      • JOEL E DIMSDALE, MDDistinguished Professor of Psychiatry Emeritus, Department of Psychiatry, University of California, San Diego, La Jolla, CA

      Somatic symptoms that cannot be attributed to organic disease account for 15 to 20% of primary care consultations and up to 50% in specialized settings. About 6% of the general population has chronic somatic symptoms that affect functioning and quality of life. This chapter focuses on the recognition and effective management of patients with excessive and disabling somatic symptoms. The clinical presentation of somatic symptoms is categorized into three groups of patients: those with multiple somatic symptoms, those with health anxiety, and those with conversion disorder. The chapter provides information to assist with making a diagnosis and differential diagnosis. Management includes ways to improve the physician–patient interaction that will benefit the patient, a step-care model based on illness severity and complexity, and psychological and pharmacologic treatment. The chapter is enhanced by figures and tables that summarize health anxiety, symptoms, differential diagnoses, and management strategies, as well as by case studies and examples.

      This review contains  5 highly rendered figures, 10 tables, and 235 references.

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    • 11

      Depressive Disorders: Update on Diagnosis, Etiology, and Treatment

      By Isabelle E. Bauer, PhD; Antonio L Teixeira, MD, PhD; Marsal Sanches, MD, PhD; Jair C. Soares, MD
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      Depressive Disorders: Update on Diagnosis, Etiology, and Treatment

      • ISABELLE E. BAUER, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • ANTONIO L TEIXEIRA, MD, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • MARSAL SANCHES, MD, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • JAIR C. SOARES, MDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX

      This review discusses the changes in the diagnostic criteria for depressive disorders as outlined in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), and recent findings exploring the etiology of and treatment strategies for these disorders. Depressive disorders are typically characterized by depression in the absence of a lifetime history of mania or hypomania. New developments in the DSM-5 include the recognition of new types of depressive disorders, such as disruptive mood dysregulation disorder, persistent depressive disorder, premenstrual dysphoric disorder, and the addition of catatonic features as a specifier for persistent depressive disorder. These diagnostic changes have important implications for the prognosis and treatment of this condition. A thorough understanding of both the clinical phenotype and the biosignature of these conditions is essential to provide individualized, long-term, effective treatments to affected individuals. 

      This review contains 6 table and 53 references

      Key words: brain volumes, depressive disorders, DSM-5, hormones, inflammation, neuropeptides, somatic therapy, stress

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    • 12

      Personality Disorders

      By Yosefa A. Ehrlich, BS; Amir Garakani, MD; Larry Siever, MD; Stephanie R Pavlos, MA
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      Personality Disorders

      • YOSEFA A. EHRLICH, BSDoctoral Student in Clinical Psychology, City University of New York Graduate Center, New York, NY
      • AMIR GARAKANI, MDAssistant Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY
      • LARRY SIEVER, MDProfessor of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY
      • STEPHANIE R PAVLOS, MADoctoral Student in Clinical Psychology, St. Johns University, Queens, NY

      Personality can be defined as an organizational system of self that shapes the manner in which a person interacts with his or her environment. Personality traits develop in adolescence or early adulthood and are thought to be shaped by early childhood experiences and enduring throughout a lifetime. Personality traits that prevent an individual from being able to function in society or that cause significant distress are diagnosed as personality disorders. A thorough history is needed to rule out other psychiatric and medical disorders. This chapter reviews the diagnostic criteria, differential diagnosis, comorbidity, prevalence, etiology (including genetics and neurobiology), prognosis, and treatment of paranoid, schizoid, schizotypal, borderline, antisocial, narcissistic, histrionic, avoidant, obsessive-compulsive, and dependent personality disorders. A discussion of the relevance of personality disorders to primary care practices and approaches to managing such patients is also included. Tables describe the diagnostic criteria of each personality disorder. Figures illustrate the prevalence of personality disorders in the general and psychiatric populations; schizotypal personality disorder in the community, general population, and clinical population; childhood trauma in individuals with personality disorder; and comorbid disorders in individuals with borderline personality disorder. A model of brain processing in borderline personality disorder is also featured.

      This chapter contains 5 highly rendered figures, 10 tables, 230 references, and 5 MCQs.

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    • 13

      Bipolar Disorder: an Update on Diagnosis, Etiology, and Treatment

      By Isabelle E. Bauer, PhD; Antonio L Teixeira, MD, PhD; Marsal Sanches, MD, PhD; Jair C. Soares, MD
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      Bipolar Disorder: an Update on Diagnosis, Etiology, and Treatment

      • ISABELLE E. BAUER, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • ANTONIO L TEIXEIRA, MD, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • MARSAL SANCHES, MD, PHDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
      • JAIR C. SOARES, MDDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX

      Bipolar disorders typically involve a history of mania or hypomania alternating with depressive phases. The course of bipolar disorder is often chronic, and frequently, patients can initially present with unipolar depression only to later develop manic symptoms. This chapter reviews the changes in the diagnostic criteria for depressive disorders as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and reviews recent findings exploring the etiology and treatment strategies for these disorders. Bipolar disorder is usually treated with mood-stabilizing agents, but there is promising evidence supporting other treatment strategies, including adjunct antiinflammatory treatments and neuromodulation strategies. The use of concurrent psychotherapy for managing symptoms and medication adherence is also gaining importance.

       

      This review contains 2 tables and 52 references

      Key Words: bipolar disorder, brain volumes, cognition, DSM-5, epigenetics, genetic, neuroinflammation, psychotherapy

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    • 14

      Unhealthy Alcohol Use

      By Stephen R Holt, MD, MSc; Joseph H. Donroe, MD, MPH
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      Unhealthy Alcohol Use

      • STEPHEN R HOLT, MD, MSCAssistant Professor of Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
      • JOSEPH H. DONROE, MD, MPH Assistant Professor of Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT

      Unhealthy alcohol use refers to a spectrum of alcohol consumption ranging from at risk drinking to alcohol use disorder. It is associated with both a high cost to society and to individuals. Globally, alcohol is a leading cause of death and disability, and despite the high prevalence of unhealthy alcohol use, diagnosis and treatment of alcohol use disorder remains disproportionately low. Risk for unhealthy alcohol use and alcohol related harms is multifactorial and includes genetic factors, gender, age, socioeconomic status, cultural and societal norms, and policies regulating alcohol consumption among others. Excessive alcohol use is associated with a myriad of poor physical and mental health outcomes, and screening for unhealthy alcohol use is universally recommended and effective.          

       

      This review contains 2 figures, 6 tables and 72 rederences

      Key Words: Alcohol, Drinking, Addiction, Screening

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    • 15

      Overview of Schizophrenia and Other Psychotic Disorders

      By Donald W. Black, MD; James A. Wilcox, MD, PhD
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      Overview of Schizophrenia and Other Psychotic Disorders

      • DONALD W. BLACK, MD
      • JAMES A. WILCOX, MD, PHD

      Psychotic disorders are among the most disabling conditions and constitute a major public health problem. Described throughout recorded time, they affect as many as 5% of the population and cause a disproportionate amount of suffering and loss to society. In the chapter on schizophrenia spectrum and other psychotic disorders, the DSM-5 lists delusional disorder, brief psychotic disorder, schizophreniform disorder, schizophrenia, and schizoaffective disorder, as well as categories for substance- or medically induced psychotic disorders. The term psychosis indicates that the individual has a severe inability to interpret the surrounding environment in a realistic way. Symptoms include hallucinations, delusions, and bizarre behavior. Psychotic disorders are associated with premature death, mostly attributable to suicide. The pathophysiology and etiology of psychotic disorders are only now beginning to be understood, and treatment for these conditions remains suboptimal. Researchers are currently refining the cause of these symptoms and developing more effective treatments.  


      This review contains 2 tables, and 30 references.

      Key words:brief psychotic disorder, delusions, hallucinations, psychosis, schizoaffective disorder, schizophrenia, schizophreniform disorder 

       

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    • 16

      Overview of Substance Use Disorders

      By Alexander W Thompson, MD, MBA, MPH; Timothy Ando, MD; Emily Morse, DO
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      Overview of Substance Use Disorders

      • ALEXANDER W THOMPSON, MD, MBA, MPHClinical associate professor, Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA.
      • TIMOTHY ANDO, MDPsychiatry Resident, Department of Psychiatry, Stanford University School of Medicine, Stanford, CA
      • EMILY MORSE, DOChief Resident in Psychiatry, Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA

      Substance use disorders are a major source of morbidity and mortality, contributing to a significant proportion of deaths in the United States and worldwide each year. A substantial rise in deaths related to drug overdoses in recent decades has drawn increasing public attention to this issue. However, the majority of individuals struggling with substance use disorders remain untreated. The financial costs and health burden are substantial. This review provides a broad overview of substance-related and addictive disorders. The evolution of the classification system is described, and the diagnostic criteria for the various substance use disorders are reviewed. Epidemiology and etiologic considerations, including neurobiological pathways, genetics, environmental influences, and dimensional risk factors, are examined. Finally, individual substances and their related disorders are reviewed, including alcohol, caffeine, cannabis, hallucinogens, inhalants, opioids, sedative/hypnotics, stimulants, tobacco, and other or unknown substances. Intoxication and withdrawal syndromes are described where applicable, and clinical management concepts are discussed. 

      This review contains 6 figures, 5 tables, and 71 references.

      Key words: abuse, addiction, alcohol, caffeine, cannabis, dependence, diagnosis, DSM-5, epidemiology, hallucinogen, hypnotic, inhalant, intoxication, methamphetamine, nicotine, opioid, sedative, stimulant, substance use disorders, tobacco, tolerance, withdrawal

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  • Pulmonary
    • 1

      Asthma

      By Haitham Nsour, MBBS; Anne E. Dixon, MA, BMBCH
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      Asthma

      • HAITHAM NSOUR, MBBSAssistant Professor, Department of Medicine, University of Vermont College of Medicine, Fletcher Allen Health Care, Burlington, VT
      • ANNE E. DIXON, MA, BMBCHProfessor, Department of Medicine, University of Vermont College of Medicine, Fletcher Allen Health Care, Burlington, VT

      Asthma is one of the most common diseases in developed nations. A pathognomonic feature of asthma is episodic aggravations of the disease; these exacerbations can be life-threatening and contribute to a significant proportion of the public health burden of asthma. In the emergency department, successful management of asthma exacerbations requires early recognition and intervention before they become severe and potentially fatal. This review summarizes the pathophysiology, stabilization and assessment, diagnosis and treatment, and disposition and outcomes for asthma. Figures show the management of asthma exacerbations in the emergency department and hospital, pooled odds ratio comparing inhaled corticosteroids and oral corticosteroids with oral corticosteroids alone following emergency department discharge, and an asthma discharge plan at the emergency department. Tables list current asthma prevalence among selected demographic groups in the United States, risk factors for fatal asthma exacerbations, differential diagnosis of asthma exacerbations, and dosages of drugs for asthma exacerbations.

      This review contains 2 figures, 14 tables, and 86 references.

      Key Words: Asthma, allergic bronchopulmonary aspergillosis, gastroesophageal reflux disease, sinus disease, breathlessness, shortness of breath


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    • 2

      Pulmonary Edema

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      Pulmonary Edema

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    • 3

      Basics of Pulmonary Function Testing 

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      Basics of Pulmonary Function Testing 

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    • 4

      Imaging of Lung Disease

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      Imaging of Lung Disease

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    • 5

      Sarcoidosis 

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      Sarcoidosis 

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    • 6

      Cystic Fibrosis and Bronchiectasis 

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      Cystic Fibrosis and Bronchiectasis 

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    • 7

      Idiopathic Lung Disease Including Fibrosis

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      Idiopathic Lung Disease Including Fibrosis

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    • 8

      Occupational and Environmental Lung Diseases 

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      Occupational and Environmental Lung Diseases 

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    • 9

      Pulmonary Vascular Conditions Including Pulmonary Hypertension

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      Pulmonary Vascular Conditions Including Pulmonary Hypertension

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    • 10

      Tobacco Cessation

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      Tobacco Cessation

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    • 11

      Chronic Obstructive Pulmonary Disease

      By Andrew J Schissler, MD; George Washko, MD; Carolyn E. Come, MD, MPH
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      Chronic Obstructive Pulmonary Disease

      • ANDREW J SCHISSLER, MDClinical and Research Fellow, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
      • GEORGE WASHKO, MDAssociate Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
      • CAROLYN E. COME, MD, MPHInstructor in Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

      Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death worldwide. This edition reviews the epidemiology and etiologies of COPD, including the gender effects, racial differences, and more recently identified genetic factors associated with this condition. It details the many pathogenetic mechanisms thought to be associated with this disease state, such as increased airway inflammation and turnover of extracellular matrix. There is a detailed discussion about diagnosis, classification, and the therapeutic options available for both stable disease and acute exacerbations. The recent evidence supporting various treatments, such as vaccinations, inhaled bronchodilators, inhaled corticosteroids, oral corticosteroids, antibiotics, supplemental oxygen, pulmonary rehabilitation, and surgery, is reviewed in depth. There is further evaluation of experimental approaches, such as bronchoscopic lung reduction procedures and the use of extracorporeal carbon dioxide removal for hypercapnic respiratory failure. The many complications associated with COPD are described, acknowledging that evidence continues to suggest that COPD has a significant systemic component associated with increased rates of psychiatric illness, cardiovascular disease, osteoporosis, and skeletal muscle dysfunction along with lung cancer. Overall this text serves as an excellent evidence-based guide to better understand, diagnose, and manage COPD and its array of associated complications.

      Key words: chronic obstructive pulmonary disease (COPD), COPD complications, COPD diagnosis, COPD management, COPD pathophysiology, Global Initiative for Chronic Obstructive Lung Disease (GOLD)

      This review contains 6 highly rendered figures, 4 tables, and 239 references.

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    • 12

      Approach to the Patient With Dyspnea

      By Roza Badr Eslam, MD; Aaron B Waxman, MD, PhD
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      Approach to the Patient With Dyspnea

      • ROZA BADR ESLAM, MDPulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria
      • AARON B WAXMAN, MD, PHDPulmonary and Critical Care Medicine, Director, Pulmonary Vascular Disease Program, Executive Director, Center for Pulmonary-Heart Diseases, Brigham and Women’s Hospital Heart and Vascular Center, Associate Professor of Medicine/Harvard Medical School, Boston, MA

      Dyspnea is a common, distressing symptom of cardiopulmonary and neuromuscular disease. In a consensus statement, the American Thoracic Society defined dyspnea as “a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity.” Dyspnea is a nonspecific complaint and is one of the most frequent patient complaints. This review discusses the definition, epidemiology, etiology, pathophysiology, peripheral mechanisms, and evaluation of dyspnea. Figures depict cellular metabolism and exercise physiology, and an invasive cardiopulmonary exercise testing (iCPET) flow diagram. Tables list the common causes of dyspnea, invasive cardiopulmonary exercise testing (iCPET) diagnosis, and iCPET characteristics of pulmonary hypertension.

      This review contains 2 highly rendered figures, 3 tables, and 51 references.

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    • 13

      Approach to the Patient With Cough

      By Christopher H. Fanta, MD
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      Approach to the Patient With Cough

      • CHRISTOPHER H. FANTA, MDDirector, Partners Asthma Center; Member, Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital; and Professor of Medicine, Harvard Medical School, Boston, MA

      The cough reflex is critically important in the clearance of abnormal airway secretions and protection of the lower respiratory tract from aspirated foreign matter. A weak or ineffective cough can lead to respiratory compromise from even a relatively minor bronchial infection. Persistent cough is often one of a constellation of symptoms indicative of respiratory disease—a potential clue in the differential diagnosis of the patient’s illness. Given the widespread distribution of sensory nerve endings of the cough reflex throughout the upper and lower respiratory tract, it is not surprising that myriad respiratory diseases, involving lung parenchyma and airways, can manifest with cough. Sometimes cough is the sole or predominant symptom in a patient who is otherwise well. Evaluating and treating the patient with persistent cough who has few, if any, other respiratory symptoms is a common challenge for the practicing physician. This review covers the normal cough mechanism, impaired cough, pathologic cough, cough suppressant therapy, and new developments. Figures show a flow-volume loop during cough, a posteroanterior chest x-ray in a patient presenting with chronic cough, flow-volume curves and spirograms documenting expiratory airflow obstruction, and the approach to the patient with chronic cough. The table lists selected examples of extrapulmonary physical findings of potential importance in the assessment of cough.

      This review contains 4 highly rendered figures, 1 table, and 94 references.

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    • 14

      Upper Airway Disorders

      By Lawrence Proano, MD, DTMH ; Seth Gemme, MD; Robert Partridge, MD, MPH, DTMH
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      Upper Airway Disorders

      • LAWRENCE PROANO, MD, DTMH Clinical Professor of Emergency Medicine, The Alpert Medical School of Brown University, Providence, RI
      • SETH GEMME, MDRhode Island Hospital; Chief Resident, The Alpert Medical School of Brown University, Providence, RI
      • ROBERT PARTRIDGE, MD, MPH, DTMH Adjunct Associate Professor of Emergency Medicine, he Alpert Medical School of Brown University, Providence, RI

      Upper airway disorders are frequently encountered in the primary care setting and present in both adults and children.  This review covers earache, sinusitis, sore throat, peritonsillar abscess, sialolithiasis and sialadenitis, parotitis, epiglottitis, epistaxis, foreign body in the ear, nose, or throat, and Ludwig angina. Figures show right-sided peritonsillar abscess demonstrating swelling and distortion of the anterior and posterior tonsillar pillars and uvular deviation, peritonsillar abscess demonstrated by an ultrasound image of a hypoechoic fluid collection, ultrasound imaging of sagittal view of the tonsillar pillars, lateral radiograph of the neck demonstrating a swollen epiglottis and widened vallecula, photographs of brawny swelling of the submandibular region of the neck in Ludwig angina, and a patient with peritonsillar abscess with extension to the base of the tongue. Tables list criteria for diagnosing acute sinusitis, and clinical presentations that best identify patients with acute bacterial versus viral rhinosinusitis.

       

      This review contains 7 figures, 11 tables, and 61 references.

      Key words: Epiglottitis, epistaxis, parotitis, peritonsillar abscess, pharyngitis, sialolithiasis, sinusitis


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    • 15

      Respiratory Viral Infections

      By Michael G. Ison, MD, MSc
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      Respiratory Viral Infections

      • MICHAEL G. ISON, MD, MSCAssociate Professor, Divisions of Infectious Diseases & Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL

      The respiratory tract can be infected by a diverse group of viruses that produce syndromes ranging in severity from mild colds to fulminant pneumonias. Respiratory viral infections are a leading cause of morbidity, hospitalization, and mortality throughout the world; influenza and pneumonia were the most prevalent infectious causes of death during the 20th century in the United States.

      This review contains 8 figures, 17 tables and 75 references.

      Keywords: Virus, infection, respiratory tract, antiviral, pneumonia, croup, pharyngitis, epidemic, pandemic, outbreak

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  • Rheumatology
    • 1

      Spondyloarthropathies 

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      Spondyloarthropathies 

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    • 2
    • 3

      Scleroderma

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      Scleroderma

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    • 4

      Idiopathic Inflammatory Myopathies

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      Idiopathic Inflammatory Myopathies

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    • 5

      Systemic Vasculitis Syndromes

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      Systemic Vasculitis Syndromes

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    • 6

      Crystal Induced Joint Disease 

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      Crystal Induced Joint Disease 

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    • 7
    • 8

      Septic Arthritis, Septic Bursitis, and Osteomyelitis

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      Septic Arthritis, Septic Bursitis, and Osteomyelitis

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    • 9

      Patient With Complex Regional Pain Syndrome

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      Patient With Complex Regional Pain Syndrome

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    • 10

      Osteoarthritis

      By Christopher Wise, MD, FACP
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      Osteoarthritis

      • CHRISTOPHER WISE, MD, FACPRobert Irby Professor of Medicine, Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA

      Osteoarthritis is a common form of arthritis characterized by degeneration of articular cartilage and pathologic changes in surrounding bone and periarticular tissue. The disease process results in pain and dysfunction of affected joints and is a major cause of disability in the general population. Prognosis is variable; greater muscle strength, mental health, self-efficacy, social support, and aerobic exercise are associated with better outcomes. This review outlines the classification of osteoarthritis (primary and secondary) and its epidemiology and etiologic factors, including risk factors, normal articular cartilage, and pathologic changes. Diagnosis is reviewed in terms of general considerations and specific joint involvement and related complications. The differential diagnosis is discussed. Management of osteoarthritis includes nonpharmacologic measures, pharmacologic therapy, surgery, and disease-modifying or chondroprotective therapy. Tables describe causes of secondary osteoarthritis, risk factors for osteoarthritis, and treatment of osteoarthritis. Figures demonstrate the microscopic appearance of normal and osteoarthritic articular cartilage, the diagnostic process for osteoarthritis, the hands of a patient with typical primary osteoarthritis, destructive changes in the interphalangeal joints, knee radiographs, and an osteoarthritic hip joint.

      This review contains 6 highly rendered figures, 3 tables, and 113 references.

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    • 11

      Fibromyalgia

      By Daniel Joseph Clauw, MD
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      Fibromyalgia

      • DANIEL JOSEPH CLAUW, MDProfessor of Anesthesiology, Medicine and Psychiatry, Director, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI

      Clinicians often encounter individuals who present with pain that they cannot adequately explain based on the degree of damage or inflammation noted in peripheral tissues. This typically prompts an evaluation looking for a cause of the pain. If no cause is found, these individuals are often given a diagnostic label that merely connotes that the patient has chronic pain in a region of the body, without an underlying mechanistic cause. Fibromyalgia (FM) is merely the current term for widespread musculoskeletal pain for which no alternative cause can be identified. This review covers the epidemiology, etiology/genetics, pathophysiology and pathogenesis, diagnosis, differential diagnosis, treatment, and complications and prognosis of FM. Figures show underlying mechanisms that can cause chronic pain; an individual’s “set point” or “volume control setting” for pain as set by a variety of factors, including the levels of neurotransmitters that either facilitate pain or reduce pain transmission; the 2011 Fibromyalgia Survey Criteria; symptoms and syndromes frequently seen in individuals with FM; the distribution of the 2011 Fibromyalgia Survey scores in a large cohort of individuals undergoing joint replacement surgery; and an algorithm showing the importance of dually focused treatment for FM and other chronic pain conditions. Tables list clinical characteristics of centralized pain, pharmacologic therapies for FM, and nonpharmacologic therapies for FM.

      This review contains 6 highly rendered figures, 3 tables, and 99 references.

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    • 12

      Rheumatoid Arthritis: Treatment

      By Anna-Karin H. Ekwall, MD, PhD; Gary S. Firestein, MD
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      Rheumatoid Arthritis: Treatment

      • ANNA-KARIN H. EKWALL, MD, PHDSpecialist in Rheumatology, University of California San Diego School of Medicine, La Jolla, CA, Researcher/Postdoc, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
      • GARY S. FIRESTEIN, MDProfessor of Medicine, Dean and Associate Vice Chancellor of Translational Medicine, UC San Diego School of Medicine, La Jolla, California

      The main goal of treatment of rheumatoid arthritis (RA) has evolved from modest improvement to low disease activity and will soon be complete remission. To reach this goal, the rheumatologist and patient should define the goal and treatment strategy together. Disease activity should be measured regularly using validated composite measures such as disease activity score, simple disease activity index, and clinical disease activity index. Management involves efforts to relieve pain and discomfort, preserve strength and joint function, and prevent structural deformities. Surgical intervention is important for replacing destroyed joints and for restoring function and preventing further damage. This review discusses the role of drug therapy, including nonsteroidal antiinflammatory drugs, methotrexate, antimalarial drugs, sulfasalazine, leflunomide, tofacitinib, biologic drugs, T cell– and B cell–targeted therapy, glucocorticoids, and other immunosuppressive agents. Nonmedical therapy, surgery, and prognosis are also detailed. Tables include the American College of Rheumatology definition of improvement of RA and comparisons of various antirheumatic treatments using small-molecule and biologic drugs. Figures include an algorithm for pharmacologic management of RA and a graph showing mean disease activity scores.

      This review contains 2 highly rendered figures, 3 tables, and 54 references.

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    • 13

      Seronegative Spondyloarthritis: Epidemiology, Pathogenesis, and Pathology

      By Walter P Maksymowych, MB, ChB, FRCP (UK), FRCPC, FACP
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      Seronegative Spondyloarthritis: Epidemiology, Pathogenesis, and Pathology

      • WALTER P MAKSYMOWYCH, MB, CHB, FRCP (UK), FRCPC, FACPProfessor of Medicine, Department of Medicine, University of Alberta, Medical Scientist, Alberta Innovates-Health Solutions, Edmonton, AB

      Classification of spondyloarthritis (SpA) is aimed at including patients with radiographic evidence of sacroiliitis and those with early disease who do not yet meet radiographic criteria but have positive features on magnetic resonance imaging (MRI). Most studies report a prevalence of SpA of 0.1 to 0.6%. Human leukocyte antigen (HLA)-B27 contributes approximately 20% of the heritability of SpA, and non–major histocompatibility complex loci identified to date (n = 113) contribute another approximately 10%. To date, 160 subtypes of HLA-B*27 have been reported, although population-based disease association studies are limited to only a few subtypes. Subtypes HLA-B*27:05 and HLA-B*27:04 are examples of subtypes associated with disease, whereas HLA-B*27:06 and HLA-B*27:09 are nonassociated. Properties of the B27 molecule relevant to pathogenesis include antigen presentation, propensity to misfold, and formation of homodimers. Key pathways identified by genetic studies include the interleukin (IL)-23 and M1-aminopeptidase pathways. The latter pathway is involved in peptide trimming in the endoplasmic reticulum, changing both the length and amino acid composition of peptides available for HLA class I presentation. IL-23 is a key cytokine regulating expression of IL-17 in a specific T helper cell phenotype, Th17, and also a variety of cells of the innate immune system. The IL-23–IL-17 pathway has been directly implicated in inflammation at sites that are inflamed in SpA. Increasing evidence based on prospective clinical and imaging data supports a link between inflammation and ankylosis, especially if the resolution of inflammation is followed by the appearance of a particular type of reparative tissue, namely, fat metaplasia, on T1-weighted MRI.

      This review contains 8 figures, 5 tables and 33 references

      Key words: association, classification, genetics, heritability, innate immunity, prevalence, spondyloarthritis

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    • 14

      Seronegative Spondyloarthritis: Diagnosis and Management

      By Walter P Maksymowych, MB, ChB, FRCP (UK), FRCPC, FACP
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      Seronegative Spondyloarthritis: Diagnosis and Management

      • WALTER P MAKSYMOWYCH, MB, CHB, FRCP (UK), FRCPC, FACPProfessor of Medicine, Department of Medicine, University of Alberta, Medical Scientist, Alberta Innovates-Health Solutions, Edmonton, AB

      Diagnosis of spondyloarthritis is challenging in its early stages due to a lack of sensitivity and specificity of clinical and laboratory features. The advent of magnetic resonance imaging (MRI) has been transformational for diagnosis due to its ability to detect inflammation, reparative changes, and structural lesions far sooner than plain radiography. New guidelines for diagnostic evaluation now call for the early use of MRI in the setting of suspicious clinical features and where radiography of the sacroiliac joints is normal or equivocal rather than additional radiography or isotopic scanning. Standardized MRI evaluation should include a T1-weighted sequence to assess structural lesions and a water-sensitive sequence to detect inflammation. Earlier diagnosis has facilitated clinical trials of tumor necrosis factor inhibitors (TNFIs) in patients who have not yet developed full-blown radiographic sacroiliitis, and these have shown comparable efficacy to trials with TNFI agents in patients meeting the criteria for radiographic sacroiliitis. New treatment guidelines call for the use of these agents in patients with early, nonradiographic, axial disease after having failed at least two nonsteroidal antiinflammatory agents, especially in those with objective features of inflammation. Monoclonal antibody TNFIs are also beneficial for acute anterior uveitis, psoriasis, and colitis. Advances in the understanding of pathophysiology have also led to a successful trial of a biologic, secukinumab, targeting interleukin-17. Despite profound benefits for the signs and symptoms, it remains unclear whether any of these agents can prevent structural progression of disease. 

      This review contains 8 figures, 5 tables and 33 references 

      Key words: diagnosis, guidelines, magnetic resonance imaging, radiography, spondyloarthritis, treatment

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    • 15

      Systemic Lupus Erythematosus

      By Kyriakos A. Kirou, MD; Michael D. Lockshin , MD
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      Systemic Lupus Erythematosus

      • KYRIAKOS A. KIROU, MDAssistant Professor of Clinical Medicine, Weill Medical College of Cornell University, Co-director, Mary Kirkland Center for Lupus Care, Hospital for Special Surgery
      • MICHAEL D. LOCKSHIN , MDProfessor of Medicine and Obstetrics-Gynecology, Weill Medical College of Cornell University, Director, Barbara Volcker Center, Hospital for Special Surgery

      Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune illness characterized by autoantibodies directed at nuclear antigens that cause clinical and laboratory abnormalities, such as rash, arthritis, leukopenia and thrombocytopenia, alopecia, fever, nephritis, and neurologic disease. Most or all of the symptoms of acute lupus are attributable to immunologic attack on the affected organs. Many complications of long-term disease are attributable to both the disease and its treatment. Intense sun exposure, drug reactions, and infections are circumstances that induce flare; the aim of treatment is to induce remission. This chapter is divided into sections dealing with SLE’s definitions; epidemiology; pathogenesis; disease classification, diagnosis, and differential diagnosis; and treatment.

      This review contains 10 figures, 11 tables, and 97 references.

      Key Words: Systemic lupus erythematosus, Dermatomyositis, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, Discoid lupus erythematosus, truncal psoriasiform, annular polycyclic rash

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    • 16

      Introduction to the Patient With Rheumatic Disease

      By David A. Fox, MD
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      Introduction to the Patient With Rheumatic Disease

      • DAVID A. FOX, MDProfessor, Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School and Health System, Ann Arbor, MI

      The rheumatic diseases encompass a broad spectrum of conditions that include inflammatory, metabolic, and structural diseases of the joints and adjacent musculoskeletal structures, chronic musculoskeletal pain syndromes, and a wide range of systemic autoimmune and autoinflammatory diseases that may or may not have articular manifestations.

      This review contains 4 figures, 11 tables, and 25 references.

      Key Words osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, fibromyalgia, acute monoarthritis, Ankylosing spondylitis, nonradiographic axial spondyloarthritis, gouty arthritis, lupus nephritis

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  • Women's Health
    • 1

      Cervical Cancer Prevention

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      Cervical Cancer Prevention


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    • 2

      Normal and Abnormal Menstruation

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      Normal and Abnormal Menstruation


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    • 3

      Endometriosis

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      Endometriosis


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    • 4

      Special Topics in Women’s Health

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      Special Topics in Women’s Health

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    • 5

      Disease of the Pelvic Floor

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      Disease of the Pelvic Floor

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    • 6

      Primary and Preventive Care of Women

      By Janet B. Henrich, MD
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      Primary and Preventive Care of Women

      • JANET B. HENRICH, MDAssociate Professor of Medicine and Obstetrics and Gynecology, Yale University, New Haven, CT

      Women’s health can be defined as diseases or conditions that are unique to women or that involve gender differences that are particularly important to women. This definition acknowledges the increasing scientific evidence supporting a focus on sex and gender and expands the concept of women’s health beyond the traditional focus on reproductive organs and their function. Over time, the definition has come to include an appreciation of wellness and prevention, the interdisciplinary and holistic nature of women’s health, the diversity of women and their health needs over the life span, and the central role of women as patients and as active participants in their health care. This broader interdisciplinary perspective has important implications for clinicians providing care to women. In addition to understanding basic female physiology and reproductive biology, clinicians need to appreciate the complex interaction between the environment and the biology and psychosocial development of women. When dealing with conditions that are not specific to women, clinicians need to be aware of those aspects of disease that are different in women or have important gender implications. The ability to apply this information requires that clinicians adopt attitudes and behavior that are culturally and gender sensitive. Figures visualize female life expectancy, age-adjusted death rates, female breast cancer incidence and death rates, trends in female cigarette smoking, and the U.S. Preventive Services Task Force guidelines for preventive primary care in women. 


      This chapter contains 5 highly rendered figures, 52 references, 5 MCQs, and 1 teaching slide set.

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    • 7

      Infertility

      By Eric D. Levens, MD; Katherine A Green, MD; Alan H. DeCherney, MD
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      Infertility

      • ERIC D. LEVENS, MDShady Grove Fertility Reproductive Science Center, Rockville, MD
      • KATHERINE A GREEN, MDClinical Fellow, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD
      • ALAN H. DECHERNEY, MDChief, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD

      Infertility affects 12 to 18% of couples in the United States and may be due to female factors, male factors, or both. A systematic evaluation of the common causes of infertility can identify conditions that may be treated by the obstetrician-gynecologist to help the couple achieve their family-building goals or those that require referral to a subspecialist. This review discusses current recommendations regarding the workup and treatment of the common causes of infertility, including tubal and pelvic factors, ovulatory disorders, and male factors. Advances in assisted reproductive technology are also discussed, including the use of genetic screening in in vitro fertilization and fertility preservation options for individuals facing gonadotoxic therapy.

      This review contains 6 figures, 6 tables, and 50 references.

      Key words: anovulation, assisted reproductive technology, clomiphene citrate, infertility, letrozole, oocyte cryopreservation, ovulation induction, semen analysis, tubal factor, uterine factor

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    • 8

      Contraception

      By Siripanth Nippita, MD, MS; Eva Luo, MD, MBA
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      Contraception

      • SIRIPANTH NIPPITA, MD, MSBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
      • EVA LUO, MD, MBABeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

      Most individuals will wish to avoid pregnancy for some part of their reproductive years. A variety of hormonal and nonhormonal contraceptive methods are available, which have different characteristics related to systemic effects, bleeding patterns, and effort required on the user’s part. The goal of contraceptive counseling is to identify a method that is safe and compatible with the individual’s preferences. Clinicians may often be able to help patients initiate contraception on the day of the initial office visit. They should remain available and supportive to patients who wish to switch methods and provide comprehensive counseling for all available contraceptive methods as well as emergency contraception options.

      This review contains 8 figures, 6 tables and 47 references.

       Key words: birth control, contraception, emergency contraception, Essure, hysteroscopy, interval, laparoscopy, microinserts, postpartum, salpingectomy, sterilization

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    • 9

      Menopause

      By Susan D. Reed, MD, MPH; Eliza L. Sutton, MD, FACP
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      Menopause

      • SUSAN D. REED, MD, MPHProfessor, Department of Obstetrics and Gynecology, Department of Epidemiology, Director, Women’s Reproductive Health Research Program, University of Washington School of Medicine, Chief of Service, Obstetrics and Gynecology, Harborview Medical Center, Seattle, WA
      • ELIZA L. SUTTON, MD, FACPAssociate Professor, Division of General Internal Medicine, Department of Medicine, Medical Director, Women’s Health Care Center, University of Washington Medical Center, Seattle, WA

      The female reproductive system matures in a continuous, natural process from menarche to menopause as the finite numbers of oocytes produced during fetal development are gradually lost to ovulation and senescence. Menopause is defined as the permanent cessation of menses; by convention, the diagnosis of menopause is not made until the individual has had 12 months of amenorrhea. Menopause is thus characterized by the menstrual changes that reflect oocyte depletion and subsequent changes in ovarian hormone production. However, hormonal changes, rather than the cessation of menstruation itself, cause the manifestations that occur around the time of menopause. Therefore, a woman who has undergone a hysterectomy but who retains her ovaries can experience normal menopausal symptoms as oocyte depletion leads to changes in estrogen levels, even though cessation of menstruation occurred with surgery. This review covers definitions, natural menopause, menopausal transition and postmenopausal symptom management, and premature ovarian insufficiency. Figures show stages of reproductive aging, serum concentrations of hormones during menopausal transition and postmenopause, hormonal changes associated with reproductive aging, symptoms of menopausal transition and menopause, treatment algorithm(s), and Women’s Health Initiative findings: risks and benefits of estrogen alone and estrogen plus progestin by age group: 50 to 59, 60 to 69, and 70 to 79 years. Tables list target tissues, physical manifestations, and menopausal symptoms; selective estrogen receptor modulators used in postmenopausal women; differential diagnosis and evaluation of common menopausal symptoms; estrogen doses; progestogen dosing for endometrial protection; nonhormonal pharmaceutical hot flash therapies; and pharmacologic therapy for genitourinary atrophy.

      This review contains 6 highly rendered figures, 7 tables, and 119 references.

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    • 10

      Premenstrual Syndrome

      By Jessica B Spencer, MD, MSc; Sarah L Berga, MD
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      Premenstrual Syndrome

      • JESSICA B SPENCER, MD, MSCAssistant Professor, Department of Gynecology and Obstetrics, Emory University School of Medicine, Altlanta, GA
      • SARAH L BERGA, MDJames Robert McCord Professor and Chairman, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA

      Premenstrual syndrome (PMS) is a recurrent constellation of affective and physical symptoms that begin during the luteal phase of the menstrual cycle and resolve completely or almost completely during the follicular phase. Symptoms range in severity from mild to severe. The pathophysiology of PMS is discussed in this chapter, and potential causes are listed in a table. The diagnosis and differential diagnosis are reviewed. To warrant medical attention, evaluation, and intervention, premenstrual symptoms must be recurrent and sufficiently severe to interfere with daily work and social activities. Mild cases of PMS can be treated with lifestyle modification (e.g., good sleep patterns, regular exercise) and nonpharmacologic therapy (e.g., bright-light therapy, stress management, behavioral therapy). More severe cases warrant aggressive intervention, with pharmacologic therapy and even surgery in women who respond very well to a gonadotropin-releasing hormone (GnRH) agonist and have completed childbearing.

      This review contains 1 figure, 4 tables and 50 references

      Key Words: Premenstrual syndrome, premenstrual dysphoric disorder, selective serotonin reuptake inhibitors, anxiogenic progesterone metabolites, estrogen, progesterone.

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  • Pediatrics
    • 1

      Care of the Newborn

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      Care of the Newborn

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    • 2

      Well Infant and Child Care Including Vaccination Schedules

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      Well Infant and Child Care Including Vaccination Schedules

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    • 3

      Failure to Thrive

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      Failure to Thrive

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    • 4
    • 5

      Special Topics in Adolescent Medicine 

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      Special Topics in Adolescent Medicine 

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    • 6

      Pediatric Obesity

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      Pediatric Obesity

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    • 7

      Diabetes

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      Diabetes

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    • 8

      Cystic Fibrosis

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      Cystic Fibrosis

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    • 9

      Common Rashes 

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      Common Rashes 

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    • 10

      Infections of the Ears, Nose and Throat (otitis Media/externa, Sinusitis, Pharyngitis)

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      Infections of the Ears, Nose and Throat (otitis Media/externa, Sinusitis, Pharyngitis)

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    • 11

      Upper Respiratory Tract Infections (including Bronchitis, Pharyngitis, Sinusitis, Otitis)

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      Upper Respiratory Tract Infections (including Bronchitis, Pharyngitis, Sinusitis, Otitis)

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    • 12

      Approach to Constipation and Abdominal Pain

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      Approach to Constipation and Abdominal Pain

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    • 13

      Approach to Diarrhea and Bloody Stool

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      Approach to Diarrhea and Bloody Stool

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    • 14

      Vomiting and Dehydration

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      Vomiting and Dehydration

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    • 15

      Pediatric Bone and Joint Diseases/injuries (legg Calve Perthes, Osgood-shlatter, Compartment Syndrome, Nursemaid’s Elbow)

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      Pediatric Bone and Joint Diseases/injuries (legg Calve Perthes, Osgood-shlatter, Compartment Syndrome, Nursemaid’s Elbow)

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    • 16

      Evaluation of Head Trauma 

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      Evaluation of Head Trauma 

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    • 17

      Management of Behavioral Issues Including ADD/ADHD

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      Management of Behavioral Issues Including ADD/ADHD

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    • 18

      Pediatric Minor Head Injury and Concussion

      By Chad Scarboro, MD; Simone Lawson, MD
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      Pediatric Minor Head Injury and Concussion

      • CHAD SCARBORO, MDAssistant Professor, Department of Emergency Medicine/Pediatric Emergency Medicine, Carolinas Medical Center, Charlotte, NC
      • SIMONE LAWSON, MDPediatric Emergency Medicine Fellow, Department of Emergency Medicine/Pediatric Emergency Medicine, Carolinas Medical Center, Charlotte, NC

      Head injury is one of the most common reasons children present to the emergency department (ED) and the leading cause of pediatric death and disability. Head injuries can range from having no neurologic deficits to death. Management in the ED centers on determining if there is a serious brain injury and preventing secondary brain injury. In most cases of mild traumatic brain injury, serious injuries can be ruled out based on the history of the injury, associated symptoms, and clinical assessment. Concussion is a common presentation of head injury and encompasses a wide range of symptoms. Computed tomography should be used judiciously, and extensive research has led to algorithms to aid in this decision. Prior to discharge from the ED, parents will often have questions about when their child may resume normal activity. This is a decision that most often will involve the patient’s primary care provider or a concussion specialist as the ED provider is unable to follow progression or resolution of symptoms. However, the ED provider should be able to provide anticipatory guidance.

       

      Key words: computed tomography, concussion, head injury, mild traumatic brain injury, traumatic brain injury

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    • 19

      Pediatric Rashes

      By Summer Stears-Ellis, MD
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      Pediatric Rashes

      • SUMMER STEARS-ELLIS, MDClinical Instructor, Emergency Ultrasound Fellow, Department of Emergency Medicine, The University of Arizona, Tucson, AZ

      Pediatric rashes are a common chief complaint in the emergency department (ED) and a source of anxiety for both parents and providers. Many of these rashes will not require intervention aside from symptomatic relief and parental reassurance. However, there is a subset of rashes that are the result of underlying life-threatening conditions that will warrant immediate intervention and treatment to prevent further deterioration and possible death. This review focuses on outlining the pathology of seven potentially deadly pediatric rashes that ED physicians are likely to encounter, how they present, and how to treat and manage them according to the most recent available guidelines. Figures show primary lesions, pattern of lesions, and distribution of rash associated with bacterial meningitis, toxic shock syndrome (TSS), Rocky Mountain spotted fever, Stevens-Johnson syndrome/toxic epidermal necrolysis, erythema multiforme minor and major, necrotizing fasciitis, and Henoch-Schönlein purpura. Tables list bacterial meningitis antibiotic treatment, Centers for Disease Control and Prevention clinical and laboratory criteria for TSS, TSS antibiotic treatment regimens, scoring systems for toxic epidermal necrolysis and necrotizing fasciitis, and the latest guidelines as of June 2017.

      This review contains 9 Figures, 12 Tables and 50 references

      Key words: Pediatric rash, toxic shock syndrome, skin rash, rash distribution, Rocky Mountain spotted fever, Stevens-Johnson syndrome, toxic epidermal necrolysis,  necrotizing fasciitis, Henoch-Schönlein purpura

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    • 20

      Pediatric Fever

      By Clifford C. Ellingson, MD; Dale P. Woolridge, MD, PhD
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      Pediatric Fever

      • CLIFFORD C. ELLINGSON, MDDepartment of Pediatric and Emergency Medicine, University of Arizona and Banner University Medical Center, Tucson, AZ
      • DALE P. WOOLRIDGE, MD, PHDProfessor, Department of Pediatric and Emergency Medicine, University of Arizona, Tucson, AZ

      Fever is one of the most common chief complaints among pediatric emergency departments. The evaluation and approach to a pediatric fever can be challenging. Although most cases of fever are viral in origin, the potential for a deadly bacterial infection would make even the most seasoned practitioner attentive. This review discusses the initial assessment of the pediatric patient and both necessary and recommended workups for pediatric fevers among various age groups. Common infections of bacterial and viral causes for fever are discussed and treatment recommendations offered. 

       

      This review contains 3 figures, 9 Tables and 48 references

      Key words: Pediatric fever, otitis media, pneumonia, urinary tract infection, neonatal sepsis, bacteremia, meningitis, serious bacterial infection, viral illness.

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    • 21

      Pediatric Upper Airway Obstruction

      By Michael W. Chan, MD; Suzanne M. Schmidt, MD
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      Pediatric Upper Airway Obstruction

      • MICHAEL W. CHAN, MDFellow, Pediatric Emergency Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL
      • SUZANNE M. SCHMIDT, MD Attending Physician, Pediatric Emergency Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Assistant Professor, Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL

      Upper airway obstruction is a common reason that children present for emergency care, and causes range from simple and benign etiologies to life-threatening conditions requiring emergent intervention. Both congenital and acquired conditions can result in airway obstruction at various levels, and due to the high risk of acute decompensation associated with some of these conditions, rapid diagnosis and treatment are essential. This review covers assessment and stabilization, diagnosis, and treatment of foreign-body aspiration, croup, bacterial tracheitis, epiglottitis, peritonsillar abscess, and retropharyngeal abscess. Figures show a diagram of the pediatric airway, an anteroposterior radiograph of the neck demonstrating the characteristic “steeple sign” in croup, an algorithm for the treatment of croup, lateral radiographs demonstrating a thickened epiglottis, consistent with a diagnosis of epiglottitis,  and a widening of the prevertebral soft tissues of the neck, consistent with a diagnosis of retropharyngeal abscess. Tables list causes of upper airway obstruction by anatomic location, symptoms of upper airway obstruction by anatomic location, severity of croup, and microbiology of deep neck abscesses.

       

      This review contains 5 figures, 10 tables, and 32 references

      Key words: Upper airway obstruction; Pediatric upper airway obstruction, Foreign-body aspiration, Croup, Bacterial tracheitis, Epiglottitis, Peritonsillar abscess, Retropharyngeal abscess, Stridor

       

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    • 22

      Pediatric Hematologic and Oncologic Emergencies

      By Rebecca Milligan, MD; Jenny Mendelson, MD
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      Pediatric Hematologic and Oncologic Emergencies

      • REBECCA MILLIGAN, MD
      • JENNY MENDELSON, MD

      Hematologic and oncologic emergencies that afflict children and adolescents are important for emergency medicine physicians to recognize. Pediatric patients can present with a previous formal diagnosis and have a complication related to their disease or with new symptoms that suggest a hematologic or oncologic process. Oncologic treatments can also lead to life-threatening complications. Recognizing these emergencies is very important for emergency physicians to prevent further morbidity. This review covers common patient presentations, diagnosis, and treatments for hematologic and oncologic emergencies.

       This review contains 6 figures, 7 tables and 48 references

      Key words: hematology, hemophilia, immune thrombocytopenia, neutropenic fever, oncology, pediatric, sickle cell anemia, tumor lysis syndrome, von Willebrand disease

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    • 23

      Pediatric Orthopedic Emergencies

      By Priya Gopwani, MD; Joy Koopmans, MD
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      Pediatric Orthopedic Emergencies

      • PRIYA GOPWANI, MDAttending Physician, Assistant Professor of Pediatric Emergency Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL
      • JOY KOOPMANS, MDAttending Physician, Department of Pediatric Emergency Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago at Central DuPage Hospital, Health Systems Clinician, Northwestern University Feinberg School of Medicine, Winfield, IL

      Proper care of orthopedic injuries and emergencies in children and adolescents requires knowledge of the altered bone and ligament characteristics, varying stages of skeletal development, and potential for congenital or developmental abnormalities. Pediatric fractures affecting the growth plate require unique management to maintain optimal growth. Whereas some specific fractures in these skeletally immature patients require urgent surgical repair, other fractures remodel extremely well and can be managed with a simple splint. Particular dislocations are common in this population and may have concomitant fractures. There are several overuse injuries seen primarily in children, and treatment aims to keep the patient active while allowing the injury to heal. Potentially devastating osteoarticular infections occur in the pediatric population and must be differentiated from more benign causes of joint pain, such as transient synovitis or congenital abnormalities. Children are also at risk for abnormalities such as slipped capital femoral epiphysis or Legg-Calvé-Perthes disease, which are rarely diagnosed in the adult population. It is imperative for a clinician to be aware of these and other nuances to optimally care for orthopedic injuries and emergencies in the pediatric population.

      This review contains 9 figures, 13 tables and 45 references

      Key words: bone, musculoskeletal, orthopedic, skeletal

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    • 24

      Pediatric Abdominal Emergencies

      By Jeffrey Bullard-Berent, MD, FAAP, FACEP; Aaron Kornblith, MD
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      Pediatric Abdominal Emergencies

      • JEFFREY BULLARD-BERENT, MD, FAAP, FACEPVice Chair, Emergency Medicine, Medical Director, Child Ready Virtual Pediatric Emergency Department, Professor of Emergency Medicine and Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM
      • AARON KORNBLITH, MDAssistant Professor, Emergency Medicine and Pediatrics, Benioff Children’s Hospital, San Francisco, University of California, San Francisco, San Francisco, CA

      Pediatric abdominal emergencies represent a diverse group of conditions affecting children of all ages and are a common cause of emergency department visits. The challenge for emergency physicians is discerning which child presenting with the common complaints of abdominal pain, nausea, vomiting, and diarrhea has an abdominal emergency. The emergency physician must use a thorough history, developmentally appropriate examination skills, and integration of his or her knowledge base to arrive at the correct diagnosis. This review evaluates the most common pediatric abdominal emergencies organized by chronicity from birth to adolescents: midgut volvulus, infantile hypertrophic pyloric stenosis, incarcerated inguinal hernia, ileocecal intussusception, Meckel diverticulum, and appendicitis. Readers will understand common presentations as well as the evaluation and treatment options for each diagnosis.  

      This review contains 7 figures, 6 tables and 61 references


      Key words: abdominal pain, appendicitis, hernia, hypertrophic pyloric stenosis, intussusception, Meckel diverticulum, midgut volvulus 

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    • 25

      Child Abuse and Nonaccidental Trauma

      By S Terez Malka, MD
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      Child Abuse and Nonaccidental Trauma

      • S TEREZ MALKA, MDAssistant Professor, Department of Emergency Medicine, Department of Pediatric Emergency Medicine, Massachusetts General Hospital, Boston, MA.

      Child abuse accounts for over 1% of visits to pediatric emergency departments (EDs), and injuries related to abuse have higher morbidity and mortality than accidental injuries. Recognizing child abuse and neglect in the ED is challenging but critical to prevent recurrent episodes of abuse and long-term physical and emotional sequelae. This review defines child abuse and neglect and explores historical and physical examination findings, assessment and diagnosis, treatment, disposition, and outcomes for victims of child abuse. Figures show x-rays demonstrating common fracture patterns associated with abusive injury and an algorithm for evaluation of nonaccidental trauma in the ED. Tables list key historical elements in the evaluation for abuse or neglect, bruising characteristics suggestive of abuse, fractures that are specific for abuse, and recommended laboratory evaluation for suspected abuse. 

      This review contains 4 figures, 5 tables, and 36 references.

      Key words: child abuse, child neglect, nonaccidental trauma, sexual abuse

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    • 26

      Failure to Thrive in Infants and Toddlers

      By Madhura Y Phadke, MD; Anthony F Porto, MD, MPH
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      Failure to Thrive in Infants and Toddlers

      • MADHURA Y PHADKE, MDFellow, Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT
      • ANTHONY F PORTO, MD, MPHAssistant Professor of Pediatrics, Associate Clinical Chief, Pediatric Gastroenterology, Yale University School of Medicine, New Haven, CT

      Failure to thrive (FTT) is a broad term that is used to document an abnormal pattern of weight gain over time. There is no single definition for FTT, but all proposed definitions use anthropometric parameters such as weight gain or weight for length. The term FTT has been falling out of favor, and the term weight/growth faltering is becoming more common to describe this clinical entity. The underlying problem in FTT is inadequate usable calories. The primary mechanisms leading to FTT are impaired absorption, increased metabolic demands, and inadequate caloric intake. Inadequate caloric intake is the most common of these mechanisms, although FTT is often a combination of the three. The diagnostic evaluation of FTT must take into account the multifactorial nature of this clinical sign. A comprehensive history is essential for diagnosis and should include specific questions about the child’s living situation and feeding habits. The physical examination must include accurate weight and length measurements. Clinicians should look for signs of abuse or neglect, dysmorphic features, abnormal skin or nail findings, digital clubbing, or other signs of chronic disease. Laboratory investigations are rarely revealing in FTT but should be considered if there is a high index of suspicion for underlying disease. Treatment in FTT favors a multidisciplinary approach. The primary goal of treatment is restoration of normal growth velocity. Children with FTT are at increased risk for growth and cognitive problems in later childhood, although the clinical significance of these findings is not well understood. The mainstay of treatment is increasing calories in the diet. Enteral feeding, orally or via a tube, is always preferred over parenteral feeding due to a better safety profile, ease of feeding, and lower cost. Parenteral nutrition is an acceptable way to meet caloric needs in infants and children when enteral nutrition is not possible. Children with FTT and malnutrition should be monitored closely for refeeding syndrome, which results from fluid and electrolyte shifts in malnourished children. In general, FTT can be treated on an outpatient basis with close follow-up. Indications for hospitalization include severe malnutrition/dehydration and concern for child endangerment.

      This review contains 7 figures, 8 tables and 26 references

      Key words: enteral feeding, failure to thrive, growth charts, nutrition, parenteral nutrition, poor weight gain, tube feeding, weight loss

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    • 27

      Pediatric Infectious Diarrhea and Dehydration

      By Scott McCorvey, MD, MS; John W. Martel, MD, PhD
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      Pediatric Infectious Diarrhea and Dehydration

      • SCOTT MCCORVEY, MD, MSResident, Department of Emergency Medicine, Maine Medical Center, Portland, ME
      • JOHN W. MARTEL, MD, PHDAssistant Professor, Department of Emergency Medicine, Tufts University School of Medicine, Maine Medical Center, Portland, ME

      Diarrhea is a common emergency department (ED) complaint, leading to more than 1.5 million outpatient visits and 200,000 hospital admissions in the United States alone. Although concomitant dehydration also exists in some cases, there are no standard clinical criteria to aid in identifying those children who merit intravenous resuscitation. Current pediatric volume repletion guidelines are based primarily on the estimated degree of volume depletion per the World Health Organization, Centers for Disease Control and Prevention, and American Academy of Pediatrics criteria. These practice guidelines stratify patients into mild (3 to 5% volume depletion), moderate (5 to 10% volume depletion), and severe (> 10% volume depletion). 

      This review contains 5 figures, 9 tables, and 64 references.

      Key Words: Clostridium difficile, dehydration, diarrhea, gastroenteritis, hemolytic-uremic syndrome, pediatrics

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    • 28

      Evaluation and Treatment of Pediatric Obesity

      By Nirav K Desai; Samir Softic
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      Evaluation and Treatment of Pediatric Obesity

      • NIRAV K DESAIInstructor in Pediatrics, Harvard Medical School, Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA
      • SAMIR SOFTICInstructor in Pediatrics, Harvard Medical School, Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA

      Obesity is one of the most significant health problems facing children and adolescents. The definition of overweight in children is a body mass index between the 85th and less than 95th percentile, whereas obesity is greater than or equal to the 95th percentile for age and sex. There are multiple comorbidities associated with obesity, including dyslipidemia, hypertension, type 2 diabetes, sleep apnea, and nonalcoholic fatty liver disease, as well as psychosocial issues. 


      This review contains 3 figures, 4 tables and 63 references.

      Key Words bariatric surgery, metabolic syndrome, obesity treatment, pediatric obesity, weight loss surgery

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  • Obstetrics
    • 1

      Placental Abnormalities 

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      Placental Abnormalities 

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    • 2

      Antenatal Care, Fetal Monitoring, Labor Anesthesia

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      Antenatal Care, Fetal Monitoring, Labor Anesthesia

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    • 3

      Complicated Vaginal Delivery

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      Complicated Vaginal Delivery

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    • 4

      Post-partum Care

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      Post-partum Care

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    • 5

      Diabetes in Pregnancy

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      Diabetes in Pregnancy

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    • 6

      Hypertensive Disorders in Pregnancy

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      Hypertensive Disorders in Pregnancy

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    • 7

      Anemia and Bleeding in Pregnancy

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      Anemia and Bleeding in Pregnancy

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    • 8

      Medical Complications in Pregnancy

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      Medical Complications in Pregnancy

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    • 9

      Infections in Pregnancy

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      Infections in Pregnancy

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    • 10

      First Trimester Pelvic Pain and Bleeding

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      First Trimester Pelvic Pain and Bleeding

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    • 11

      Common Medication Safety in Pregnancy

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      Common Medication Safety in Pregnancy

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    • 12

      Polycystic Ovary Syndrome

      By Snigdha Alur-Gupta, MD; Anuja Dokras, MD, PhD
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      Polycystic Ovary Syndrome

      • SNIGDHA ALUR-GUPTA, MDDivision of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA
      • ANUJA DOKRAS, MD, PHDDivision of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA

      Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder in women of reproductive age. In this review, the pathophysiology and current diagnostic criteria for PCOS are reviewed. Treatment options for symptoms commonly associated with PCOS such as hirsutism, acne, and menstrual irregularity are reviewed. Combined hormonal contraceptives are the first line of therapy in women not attempting pregnancy. The metabolic complications commonly associated with PCOS are impaired glucose tolerance and dyslipidemia. A summary of the current guidelines on screening and prevention of these complications is presented. In addition, PCOS is associated with an increased risk of depressive symptoms and anxiety disorders for which patients should be monitored.

      This review contains 5 tables and 57 references. 

      Keywords: Polycystic ovary syndrome, PCOS 

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  • Sports Medicine
    • 1

      Concussion

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      Concussion

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    • 2

      Female Athlete Triad

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      Female Athlete Triad

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    • 3
    • 4

      Stress Fractures and Metabolism

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      Stress Fractures and Metabolism

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    • 5

      Sports Hernias 

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      Sports Hernias 

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    • 6

      Pes Planus 

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      Pes Planus 

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    • 7

      Rules of Tennis

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      Rules of Tennis

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    • 8

      Rules of Tennis

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      Rules of Tennis

      Lorem ipsum dolor sit amet, consectetur adipiscing elit. Curabitur ac vestibulum velit. Etiam est augue, rhoncus vitae dui eu, finibus placerat nibh. Cras non eleifend nisl, eget faucibus nibh. Praesent facilisis euismod turpis, non feugiat arcu condimentum sit amet. Phasellus maximus elit felis, in sollicitudin felis feugiat a. Nam egestas pellentesque euismod. Suspendisse eget ligula id mi blandit ultricies. Integer dignissim fermentum tellus, vitae faucibus ex suscipit quis. Donec ultricies augue et erat tincidunt mattis. Nam vitae neque sagittis, finibus sem rhoncus, scelerisque mauris. Donec egestas dignissim nunc convallis laoreet. Nam convallis semper ante non elementum. In non dolor elementum, fermentum lacus sed, efficitur tortor. Suspendisse molestie mattis mi vulputate venenatis. Integer id sapien tincidunt, faucibus diam quis, venenatis quam.

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    • 9

      Rules of Tennis

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      Rules of Tennis

      Welcome to Tennis Canada Officiating Rules of Tennis Module!

      In this session we will cover the 31 Rules of Tennis, but rather than covering the Rules in numerical order from 1 to 31, we will group them according to the following sections:

      1. Getting Started: the Court, the Ball, the Racket
      2. Scoring: Who Starts? Who Wins?
      3. The Service
      4. Playing
      5. Correcting Errors
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    • 10

      Rules of Tennis

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      Rules of Tennis

      Welcome to Tennis Canada Officiating Rules of Tennis Module!

      In this session we will cover the 31 Rules of Tennis, but rather than covering the Rules in numerical order from 1 to 31, we will group them according to the following sections:

      Getting Started: the Court, the Ball, the Racket
      Scoring: Who Starts? Who Wins?
      The Service
      Playing
      Correcting Errors
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    • 11

      Rules of Tennis

      Purchase PDF

      Rules of Tennis

      Welcome to Tennis Canada Officiating Rules of Tennis Module!

      In this session we will cover the 31 Rules of Tennis, but rather than covering the Rules in numerical order from 1 to 31, we will group them according to the following sections:

      Getting Started: the Court, the Ball, the Racket
      Scoring: Who Starts? Who Wins?
      The Service
      Playing
      Correcting Errors
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    • 12

      Rules of Tennis

      Purchase PDF

      Rules of Tennis

      Welcome to Tennis Canada Officiating Rules of Tennis Module!

      In this session we will cover the 31 Rules of Tennis, but rather than covering the Rules in numerical order from 1 to 31, we will group them according to the following sections:

      Getting Started: the Court, the Ball, the Racket
      Scoring: Who Starts? Who Wins?
      The Service
      Playing
      Correcting Errors
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    • 13

      Rules of Tennis

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      Rules of Tennis

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    • 14

      Rules of Tennis

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      Rules of Tennis

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    • 15

      Rules of Tennis

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      Rules of Tennis

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    • 16

      Rules of Tennis

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      Rules of Tennis

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    • 17

      Rules of Tennis

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      Rules of Tennis

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    • Shoulder Pain
    • Knee Pain
    • Foot and Ankle Pain
    • Elbow Pain
    • Wrist and Hand Pain
    • Disease of the Hip and Pelvis
    • Back and Neck
  • Null Product Section
    • 1
    • 2

      Rehabilitation of Geriatric Patients

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      Rehabilitation of Geriatric Patients

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    • 3

      Normal and Abnormal Menstruation

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      Normal and Abnormal Menstruation

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    • 4

      Genomics Overview

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      Genomics Overview

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    • 5

      Practice of Genetics in Clinical Medicine

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      Practice of Genetics in Clinical Medicine

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    • 6

      Infective Endocarditis

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      Infective Endocarditis

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    • 7

      Prostate Cancer

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      Prostate Cancer

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    • 8

      Quality of Care: Performance Measurement and Quality Improvement in Clinical Practice

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      Quality of Care: Performance Measurement and Quality Improvement in Clinical Practice

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    • 9

      Cutaneous Adverse Drug Reactions

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      Cutaneous Adverse Drug Reactions

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    • 10

      Symptom Management in Palliative Medicine

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      Symptom Management in Palliative Medicine

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    • 11

      Pharmacologic Approach to Renal Insufficiency

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      Pharmacologic Approach to Renal Insufficiency

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    • 12

      Adult Preventive Health Care

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      Adult Preventive Health Care

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    • 13

      Cutaneous Manifestations of Systemic Diseases

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      Cutaneous Manifestations of Systemic Diseases

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    • 14

      Management of Psychosocial Issues in Terminal Illness

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      Management of Psychosocial Issues in Terminal Illness

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    • 15

      On Being a Physician

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      On Being a Physician

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    • 16

      Papulosquamous Disorders

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      Papulosquamous Disorders

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    • 17

      Principles and Practice of Palliative Care

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      Principles and Practice of Palliative Care

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    • 18

      Multiple Sclerosis and Related Disorders

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      Multiple Sclerosis and Related Disorders

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    • 19

      Male Sexual Dysfunction

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      Male Sexual Dysfunction

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    • 20

      Motor Neuron Diseases

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      Motor Neuron Diseases

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    • 21

      Pruritus

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      Pruritus

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    • 22
    • 23

      Exercise

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      Exercise

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    • 24

      Idiopathic Inflammatory Myopathies

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      Idiopathic Inflammatory Myopathies

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    • 25

      Plasma Cell Disorders

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      Plasma Cell Disorders

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    • 26

      Women With Disabilities

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      Women With Disabilities

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    • 27

      Medical Management of Lower Extremity Manifestations of Peripheral Artery Disease

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      Medical Management of Lower Extremity Manifestations of Peripheral Artery Disease

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    • 28

      Infestations

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      Infestations

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    • 29

      Medical Evaluation of the Surgical Patient

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      Medical Evaluation of the Surgical Patient

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    • 30

      Diseases of the Nail Unit

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      Diseases of the Nail Unit

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    • 31

      Neuromuscular Junction Disorders

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      Neuromuscular Junction Disorders

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    • 32

      Irritable Bowel Syndrome With Constipation

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      Irritable Bowel Syndrome With Constipation

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    • 33

      Injuries to the Face and Jaw

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      Injuries to the Face and Jaw

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    • 34

      Practicing Evidence-based Medicine

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      Practicing Evidence-based Medicine

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    • 35

      Acute Psychosis

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      Acute Psychosis

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    • 36

      Diverticulitis and Colitis

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      Diverticulitis and Colitis

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    • 37

      Management of Bladder Cancer

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      Management of Bladder Cancer

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    • 38

      Esophageal Disorders

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      Esophageal Disorders

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    • 39

      Management of Ulcerative Colitis and Crohn Disease

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      Management of Ulcerative Colitis and Crohn Disease

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    • 40

      Pain Syndromes Other Than Headache

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      Pain Syndromes Other Than Headache

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    • 41

      Drugs of Abuse

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      Drugs of Abuse

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    • 42

      An Approach to the Patient With Abnormal Liver Tests and Jaundice

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      An Approach to the Patient With Abnormal Liver Tests and Jaundice

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    • 43

      Advance Care Planning and End of Life Decision Making

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      Advance Care Planning and End of Life Decision Making

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    • 44

      Diseases of the Stomach

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      Diseases of the Stomach

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    • 45

      General Principles of Antibiotic Therapy

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      General Principles of Antibiotic Therapy

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    • 46

      Fungal, Bacterial, and Viral Infections of the Skin

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      Fungal, Bacterial, and Viral Infections of the Skin

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    • 47

      Pediatric Seizures and Status Epilepticus

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      Pediatric Seizures and Status Epilepticus

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    • 48

      Approach to the Patient With Abdominal Pain

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      Approach to the Patient With Abdominal Pain

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    • 49

      Difficult to Treat (refractory) Chronic Migraine: Outpatient Approaches

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      Difficult to Treat (refractory) Chronic Migraine: Outpatient Approaches

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    • 50

      Hypoglycemia

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      Hypoglycemia

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    • 51

      Opioid Therapy for Chronic Noncancer Pain: Safe, Effective, Appropriate?

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      Opioid Therapy for Chronic Noncancer Pain: Safe, Effective, Appropriate?

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    • 52

      Viral Hepatitis Other Than A, B, or C

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      Viral Hepatitis Other Than A, B, or C

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    • 53

      Pediatric Minor Head Injury and Concussion

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      Pediatric Minor Head Injury and Concussion

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    • 54

      The Patient With Complex Regional Pain Syndrome

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      The Patient With Complex Regional Pain Syndrome

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    • 55

      Idiopathic Lung Diseases Other Than Pulmonary Fibrosis

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      Idiopathic Lung Diseases Other Than Pulmonary Fibrosis

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    • 56

      Urinalysis

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      Urinalysis

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    • 57

      Sarcoidosis

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      Sarcoidosis

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    • 58

      Management and Therapeutic Issues in the Dementias

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      Management and Therapeutic Issues in the Dementias

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    • 59

      Clinical Aspects of Non-alzheimer Disease Dementias

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      Clinical Aspects of Non-alzheimer Disease Dementias

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    • 60

      Approach to the Diagnosis of Skin Disease

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      Approach to the Diagnosis of Skin Disease

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    • 61

      Scleroderma and Related Disorders

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      Scleroderma and Related Disorders

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    • 62

      Congenital Heart Disease in Adults

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      Congenital Heart Disease in Adults

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    • 63

      Mood Disorders

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      Mood Disorders

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    • 64

      Cirrhosis and Complications of Portal Hypertension

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      Cirrhosis and Complications of Portal Hypertension

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    • 65

      Vascular Diseases of the Kidney

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      Vascular Diseases of the Kidney

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    • 66

      Menopause

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      Menopause

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    • 67

      Sleep Disorders

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      Sleep Disorders

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    • 68

      Lymphomas

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      Lymphomas

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    • 69

      Diverticulosis, Diverticulitis, and Appendicitis

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      Diverticulosis, Diverticulitis, and Appendicitis

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    • 70

      Urticaria and Angioedema

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      Urticaria and Angioedema

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    • 71

      Diseases of the Aorta

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      Diseases of the Aorta

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    • 72

      Anemia: Production Defects Generally Associated With Marrow Erythroid Hyperplasia and Ineffective Erythropoiesis

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      Anemia: Production Defects Generally Associated With Marrow Erythroid Hyperplasia and Ineffective Erythropoiesis

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    • 73

      Peripheral Artery Diseases

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      Peripheral Artery Diseases

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    • 74

      Occupational and Environmental Lung Diseases: Diagnosis and Prevention

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      Occupational and Environmental Lung Diseases: Diagnosis and Prevention

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    • 75

      Blunt Cerebrovascular Injuries

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      Blunt Cerebrovascular Injuries

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    • 76

      Perinatal Depression

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      Perinatal Depression

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    • 77

      Head and Neck Cancer

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      Head and Neck Cancer

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    • 78

      Nausea and Vomiting of Pregnancy

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      Nausea and Vomiting of Pregnancy

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    • 79

      The Eating Disorders

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      The Eating Disorders

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    • 80

      Chronic Kidney Failure and Dialysis

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      Chronic Kidney Failure and Dialysis

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    • 81

      Peptic Ulcer Diseases

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      Peptic Ulcer Diseases

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    • 82

      Irritable Bowel Syndrome With Diarrhea

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      Irritable Bowel Syndrome With Diarrhea

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    • 83

      Contraception

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      Contraception

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    • 84

      Depressive Disorders: Update on Diagnosis, Etiology, and Treatment

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      Depressive Disorders: Update on Diagnosis, Etiology, and Treatment

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    • 85

      Physicians' Role in Curbing the Worst Drug Crisis in America: Prescription Opioid Abuse

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      Physicians' Role in Curbing the Worst Drug Crisis in America: Prescription Opioid Abuse

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    • 86

      Approach to the Patient With Cough

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      Approach to the Patient With Cough

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    • 87

      Personality Disorders

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      Personality Disorders

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    • 88

      HIV and AIDS

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      HIV and AIDS

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    • 89

      Chronic Stable Angina

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      Chronic Stable Angina

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    • 90

      Pediatric Fever

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      Pediatric Fever

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    • 91

      Pediatric Orthopedic Emergencies

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      Pediatric Orthopedic Emergencies

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    • 92

      Medical Management of Pulmonary Arterial Hypertension

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      Medical Management of Pulmonary Arterial Hypertension

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    • 93

      Intracerebral Hemorrhage

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      Intracerebral Hemorrhage

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    • 94

      Failure to Thrive in Infants and Toddlers

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      Failure to Thrive in Infants and Toddlers

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    • 95

      Coma and Disorders of Consciousness

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      Coma and Disorders of Consciousness

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    • 96

      Headache

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      Headache

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    • 97

      Upper Airway Disorders

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      Upper Airway Disorders

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    • 98

      Type II Diabetes Mellitus

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      Type II Diabetes Mellitus

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    • 99

      Communication of Bad News

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      Communication of Bad News

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    • 100

      Premenstrual Syndrome

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      Premenstrual Syndrome

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    • 101

      Management of Chronic Kidney Disease and Its Complications

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      Management of Chronic Kidney Disease and Its Complications

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    • 102

      Principles of Neurologic Ethics

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      Principles of Neurologic Ethics

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    • 103

      Overview of Schizophrenia and Other Psychotic Disorders

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      Overview of Schizophrenia and Other Psychotic Disorders

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    • 104

      Infertility

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      Infertility

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    • 105

      Breastfeeding

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      Breastfeeding

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    • 106

      Bacterial Infections in Pregnancy

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      Bacterial Infections in Pregnancy

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    • 107

      Specific Antibiotic Agents

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      Specific Antibiotic Agents

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    • 108

      Drug Allergies

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      Drug Allergies

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    • 109

      Infections Caused by Spirochetes: Syphilis, Lyme Disease, Leptospirosis

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      Infections Caused by Spirochetes: Syphilis, Lyme Disease, Leptospirosis

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    • 110

      Epilepsy and Related Disorders

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      Epilepsy and Related Disorders

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    • 111

      Food Allergies

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      Food Allergies

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    • 112

      Overview of Posttraumatic Stress Disorder

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      Overview of Posttraumatic Stress Disorder

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    • 113

      Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases

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      Evaluation and Treatment of Monogenic Forms of Inflammatory Bowel Diseases

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    • 114

      Risk Factors and Epidemiology of Pulmonary Embolism

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      Risk Factors and Epidemiology of Pulmonary Embolism

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    • 115

      Aortic Valve Stenosis

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      Aortic Valve Stenosis

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    • 116

      Pediatric Infectious Diarrhea and Dehydration

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      Pediatric Infectious Diarrhea and Dehydration

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    • 117

      Psoriasis

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      Psoriasis

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    • 118

      Evaluation and Treatment of Pediatric Obesity

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      Evaluation and Treatment of Pediatric Obesity

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    • 119

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

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    • 120

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 121

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 122

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 123

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 124

      Back Pain and Common Musculoskeletal Problems

      Purchase PDF

      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 125

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 126

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

      Knowledge of the common nonarticular regional rheumatic disorders is important because of their high prevalence in primary care practice, the dependence on clinical findings for diagnosis, and the high cost that can result from unnecessary laboratory evaluations. The ability to recognize important patterns of pain and associated physical signs is essential to making a correct diagnosis; in most cases, radiographic and laboratory studies are not needed. This review covers the common causes of pain in the neck, back, shoulder, chest wall, elbow, hand and wrist, hip girdle, knee and lower leg, and ankle and foot.

      This review contains 5 figures, 11 tables, and 96 references.

      Key words Acute back pain, Chronic back pain, Lumbar stenosis, Shoulder pain, Chest wall pain, Elbow pain, Hand and wrist pain, Carpal Tunnel Syndrome, Hip girdle pain, Knee and lower leg pain, Ankle and foot pain

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    • 127

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

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    • 128

      Back Pain and Common Musculoskeletal Problems

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      Back Pain and Common Musculoskeletal Problems

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    • 129
    • 130

      Medical Complications in Pregnancy

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      Medical Complications in Pregnancy

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    • 131

      Diagnosis of Dyslipidemia

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      Diagnosis of Dyslipidemia

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    • 132

      Management of Dyslipidemia

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      Management of Dyslipidemia

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    • 133

      Allergic Rhinitis, Conjunctivitis, and Sinusitis

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      Allergic Rhinitis, Conjunctivitis, and Sinusitis

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    • 134
    • 135

      Allergic Response

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      Allergic Response

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    • 136

      Bacterial Infections of the Adult Upper Respiratory Tract

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      Bacterial Infections of the Adult Upper Respiratory Tract

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    • 137

      Deep Venous Thrombosis

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      Deep Venous Thrombosis

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    • 138

      The Respiratory System: Physiology

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      The Respiratory System: Physiology

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    • 139

      Late Stage Prostate Cancer

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      Late Stage Prostate Cancer

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    • 140

      Introduction to the Patient With Rheumatic Disease

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      Introduction to the Patient With Rheumatic Disease

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    • 141

      Complications of Diabetes Mellitus

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      Complications of Diabetes Mellitus

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    • 142

      Diseases of the Pericardium, Cardiac Tumors, and Cardiac Trauma

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      Diseases of the Pericardium, Cardiac Tumors, and Cardiac Trauma

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    • 143

      Diseases of Calcium Metabolism and Metabolic Bone Disease

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      Diseases of Calcium Metabolism and Metabolic Bone Disease

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    • 144

      Secondary Forms of Diabetes Mellitus

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      Secondary Forms of Diabetes Mellitus

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    • 145

      Viral Infections in Pregnancy – Part 1: CMV, Ebola Virus, Viral Hepatitis, HSV, and HIV

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      Viral Infections in Pregnancy – Part 1: CMV, Ebola Virus, Viral Hepatitis, HSV, and HIV

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    • 146

      Acne Vulgaris and Rosacea

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      Acne Vulgaris and Rosacea

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    • 147

      The Respiratory System: Physiologic Assessment and Real-world Application

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      The Respiratory System: Physiologic Assessment and Real-world Application

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    • 148

      Toxic Gases

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      Toxic Gases

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    • 149

      Respiratory System: Physiology of Mechanical Ventilation

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      Respiratory System: Physiology of Mechanical Ventilation

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    • 150

      Tuberculosis

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      Tuberculosis

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    • 151

      Nutrition Management in Mechanical Circulatory Support

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      Nutrition Management in Mechanical Circulatory Support

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    • 152

      Bipolar Disorders and Their Clinical Management, Part I: Epidemiology, Etiology, Genetics, and Neurobiology

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      Bipolar Disorders and Their Clinical Management, Part I: Epidemiology, Etiology, Genetics, and Neurobiology

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    • 153

      Bipolar Disorders and Their Clinical Management, Part II: Diagnosis, Differential Diagnosis, and Treatment

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      Bipolar Disorders and Their Clinical Management, Part II: Diagnosis, Differential Diagnosis, and Treatment

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    • 154

      Benign Prostatic Hyperplasia

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      Benign Prostatic Hyperplasia

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    • 155

      Metabolic Disorders: Inborn Errors of Carbohydrate Metabolism

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      Metabolic Disorders: Inborn Errors of Carbohydrate Metabolism

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    • 156

      Ethical and Social Issues in Medicine

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      Ethical and Social Issues in Medicine

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    • 157

      Diseases Producing Malabsorption and Maldigestion

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      Diseases Producing Malabsorption and Maldigestion

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    • 158

      Treatment of Unhealthy Alcohol Use

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      Treatment of Unhealthy Alcohol Use

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    • 159

      Crystal-induced Joint Disease

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      Crystal-induced Joint Disease

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    • 160

      Lung Cancer - Part I

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      Lung Cancer - Part I

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    • 161

      Intimate Partner Violence

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      Intimate Partner Violence

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    • 162

      Valvular Heart Disease - Part II

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      Valvular Heart Disease - Part II

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    • 163
    • 164

      Acute Kidney Injury - Part I

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      Acute Kidney Injury - Part I

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    • 165

      Acute Kidney Injury - Part II: Special Situations

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      Acute Kidney Injury - Part II: Special Situations

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    • 166

      Approach to the Patient With a Breast Mass

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      Approach to the Patient With a Breast Mass

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    • 167

      Complementary, Alternative, and Integrative Medicine

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      Complementary, Alternative, and Integrative Medicine

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    • 168

      Parkinsonism and Related Disorders

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      Parkinsonism and Related Disorders

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    • 169

      Overview of Enteral Nutrition

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      Overview of Enteral Nutrition

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    • 170

      Endometriosis

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      Endometriosis

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    • 171

      Disorders of the Pleura, Mediastinum, and Hilum

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      Disorders of the Pleura, Mediastinum, and Hilum

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    • 172

      The Clinical Use of Nonimaging Exercise Stress Testing

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      The Clinical Use of Nonimaging Exercise Stress Testing

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    • 173

      Acute Pulmonary Embolism

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      Acute Pulmonary Embolism

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    • 174

      Diseases of the Vulva

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      Diseases of the Vulva

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    • 175

      Appendicitis

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      Appendicitis

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    • 176

      Approach to the Patient With a Pelvic Mass

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      Approach to the Patient With a Pelvic Mass

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    • 177

      Abnormalities of the Fetal Chest

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      Abnormalities of the Fetal Chest

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    • 178

      Pulmonary Edema in Pregnancy

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      Pulmonary Edema in Pregnancy

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    • 179

      Abnormalities of the Fetal Head and Neck

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      Abnormalities of the Fetal Head and Neck

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    • 180

      Type I Diabetes Mellitus

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      Type I Diabetes Mellitus

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    • 181

      Cushing Syndrome

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      Cushing Syndrome

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    • 182

      Systemic Lupus Erythematosus

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      Systemic Lupus Erythematosus

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    • 183

      Ectopic Pregnancy and Spontaneous Abortion

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      Ectopic Pregnancy and Spontaneous Abortion

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    • 184

      Cardiovascular Disease in Women

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      Cardiovascular Disease in Women

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    • 185

      Vaginitis and Sexually Transmitted Diseases

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      Vaginitis and Sexually Transmitted Diseases

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    • 186

      Viral Zoonoses

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      Viral Zoonoses

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    • 187

      Disorders of Water and Sodium Balance: Hyponatremia

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      Disorders of Water and Sodium Balance: Hyponatremia

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    • 188

      Disorders of Water and Sodium Balance: Hypernatremia

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      Disorders of Water and Sodium Balance: Hypernatremia

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    • 189

      Pediatric Abdominal Emergencies

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      Pediatric Abdominal Emergencies

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    • 190

      Pulmonary Arterial Hypertension: Advancing Insights Into a Historically Neglected Disease

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      Pulmonary Arterial Hypertension: Advancing Insights Into a Historically Neglected Disease

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    • 191

      Peritoneal Dialysis

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      Peritoneal Dialysis

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    • 192

      Heritable and Acquired Thrombophilias in Clinical Practice

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      Heritable and Acquired Thrombophilias in Clinical Practice

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    • 193

      Comprehensive Overview of Pediatric Airway Management

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      Comprehensive Overview of Pediatric Airway Management

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    • 194

      Hypothyroidism and Thyrotoxicosis

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      Hypothyroidism and Thyrotoxicosis

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    • 195

      Testes and Testicular Disorders

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      Testes and Testicular Disorders

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    • 196

      Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

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      Thyroiditis, Goiter, Thyroid Nodules, and Thyroid Cancer

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    • 197

      Invasive Diagnostic and Therapeutic Techniques in Lung Disease

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      Invasive Diagnostic and Therapeutic Techniques in Lung Disease

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    • 198

      Pancreatic, Gastric, and Other Gastrointestinal Cancers

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      Pancreatic, Gastric, and Other Gastrointestinal Cancers

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    • 199

      Stroke and Other Cerebrovascular Diseases

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      Stroke and Other Cerebrovascular Diseases

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    • 200

      Diseases of the Pancreas

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      Diseases of the Pancreas

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    • 201

      Gallstones and Biliary Tract Disease

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      Gallstones and Biliary Tract Disease

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    • 202

      Achondroplasia and Hypochondroplasia

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      Achondroplasia and Hypochondroplasia

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    • 203

      Lyme Disease and Other Spirochetal Zoonoses

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      Lyme Disease and Other Spirochetal Zoonoses

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    • 204

      Attention-deficit/hyperactivity Disorder in Children and Adolescents

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      Attention-deficit/hyperactivity Disorder in Children and Adolescents

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    • 205

      Common Maternal Genetic Syndromes II: Marfan Syndrome

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      Common Maternal Genetic Syndromes II: Marfan Syndrome

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    • 206

      Fibromyalgia

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      Fibromyalgia

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    • 207

      Anaphylaxis

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      Anaphylaxis

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    • 208

      Female Sexuality: Assessing Satisfaction and Addressing Problems

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      Female Sexuality: Assessing Satisfaction and Addressing Problems

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    • 209

      Acute Ischemic Stroke and Transient Ischemic Attack

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      Acute Ischemic Stroke and Transient Ischemic Attack

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    • 210

      Respiratory Viral Infections

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      Respiratory Viral Infections

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    • 211

      Delayed Puberty

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      Delayed Puberty

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    • 212

      Coronaviruses: Hcov, Sars-cov, Mers-cov, and COVID-19

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      Coronaviruses: Hcov, Sars-cov, Mers-cov, and COVID-19

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    • 213

      Ventricular Arrhythmias

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      Ventricular Arrhythmias

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    • 214

      Vulvar Lesions in the Pediatric Patient

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      Vulvar Lesions in the Pediatric Patient

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